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Vol. 32 No. 2 (2020): Vol 32 Issue 2

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Synthesis and Antimicrobial Activity of Some Novel 1,4-Dihydropyridine Trimer Derivatives

https://doi.org/10.14233/ajchem.2020.22339
D. Ashokkumar
Department of Chemistry, Annamalai University, Annamalai Nagar-608002, India
M. Gopalakrishnan
Department of Chemistry, Annamalai University, Annamalai Nagar-608002, India
G. Ramalingam
Department of Chemistry, Annamalai University, Annamalai Nagar-608002, India

Corresponding Author(s) : G. Ramalingam

drgr_dde@rediffmail.com

Asian Journal of Chemistry, Vol. 32 No. 2 (2020): Vol 32 Issue 2

Abstract

An efficient multi-component one pot synthesis of some novel bioactive 1,4-dihydropyridine derivatives from melamine using various aldehydes and 1,3-dicarbonyl compounds are reported. This reaction carried out microwave irradiation under solvent free condition using low cost and efficient acetic acid catalyst. The excellent futures of this method are eco-friendly, short reaction time and mild reaction condition. This method is convincing route for highly substituted dihydropyridine trimer synthesis. The synthesized dihydropyridine derivatives are screened for antimicrobial properties.

Keywords

1,4-Dihydropyridines Microwave irradiation Acetic acid catalyst Antimicrobial properties
Ashokkumar, D., Gopalakrishnan, M., & Ramalingam, G. (2019). Synthesis and Antimicrobial Activity of Some Novel 1,4-Dihydropyridine Trimer Derivatives. Asian Journal of Chemistry, 32(2), 276–280. https://doi.org/10.14233/ajchem.2020.22339
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