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Vol. 32 No. 1 (2020): Vol 32 Issue 1

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Antimicrobial Activity of Copper(II) and Cobalt(II) Complexes of Citral-Valine Derived Schiff Base

https://doi.org/10.14233/ajchem.2020.21801
S. Sudha Kumari
Department of Chemistry & Research center, South Travancore Hindu College, Nagercoil-629002, India

Corresponding Author(s) : S. Sudha Kumari

sukumaris040@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 1 (2020): Vol 32 Issue 1

Abstract

In present work, the screening of antimicrobial activities of copper(II) and cobalt(II) complexes with Schiff base ligand derived from the condensation of citral with valine (amino acid) was carried out on agar plates are reported. The antibacterial activity of Schiff base and its copper(II) and cobalt(II) complexes were evaluated against two bacterial strains Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and fungus Candida albicans. The results revealed that the Schiff base ligand exhibited the poor antimicrobial activity against Escherichia coli and Candida albicans except for Staphylococcus aureus. Generally, Gram-negative bacteria shows rigid outer membrane, well enough to defend against the drug but Schiff base (citral with valine derived) impregnated cobalt(II) complex seem to be more active against Escherichia coli organisms in comparison to copper(II) complex, which exhibits higher activity than uncomplexed ligand. The antimicrobial results revealed that cobalt(II) and copper(II) complexes have a considerable antibacterial activity than antifungal activity and suggest their potential application as antibacterial agents.

Keywords

Schiff base ligand Citral Valine Antimicrobial activity Copper(II) Cobalt(II) complexes
Kumari, S. S. (2019). Antimicrobial Activity of Copper(II) and Cobalt(II) Complexes of Citral-Valine Derived Schiff Base. Asian Journal of Chemistry, 32(1), 192–194. https://doi.org/10.14233/ajchem.2020.21801
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