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Synthesis, Characterization and Enzyme Inhibition Activity of Organophosphorus Trichalcones Containing Core-Phosphate Moiety

https://doi.org/10.14233/ajchem.2020.22204
Sunil R. Khapate
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, India
Dnyaneshwar S. Wankhede
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, India
https://orcid.org/0000-0002-5787-1013
Anitha S. Deshpande
Departmentof Engineering, Ibra College of Technology, P.O. Box 327, Al Yahamadi 400, Sultanate of Oman
Neeta S. Khillare
School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded-431606, India
Anil Khandagale
School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded-431606, India

Corresponding Author(s) : Dnyaneshwar S. Wankhede

dswchem@yahoo.co.in

Asian Journal of Chemistry, Vol. 32 No. 1 (2020): Vol 32 Issue 1

Abstract

Facile synthesis of various organophosphorus trichalcones, possessing substantial insecticidal activity, by using tris(4-acetylphenyl)-phosphate (3) and substituted benzaldehydes as a precursor has been reported. Key precursor 3 has been prepared under mild conditions in presence of tetrabutylammonium bromide (TBAB) as a phase transfer catalyst. All the synthesized compounds (5a-h) were screened for their antibacterial activity and inhibition of α-amylase of insect pest, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionadeae). Biological activity evaluation study revealed that among all the compounds screened, compound 5g found to have promising inhibition of α-amylase of insect pest, Tribolium castaneum. All the synthesized compounds revealed insignificant antimicrobial activity against pathogenic bacteria even at 500 μg/mL.

Keywords

Phosphoryl chloride Tetrabutylammonium bromide Trichalcones Antibacterial activity
Khapate, S. R., Wankhede, D. S., Deshpande, A. S., Khillare, N. S., & Khandagale, A. (2019). Synthesis, Characterization and Enzyme Inhibition Activity of Organophosphorus Trichalcones Containing Core-Phosphate Moiety. Asian Journal of Chemistry, 32(1), 59–63. https://doi.org/10.14233/ajchem.2020.22204
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