Isolation and Characterization of Bioactive Anti-inflammatory Flavonoids from Arisaema tortuosum Tubers

Priyanka Chakraborty; Kamalika Mazumder; Nripendra Nath Bala; Sudipta Das

doi:10.14233/ajchem.2020.22895

Issue

Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

Issue Published : December 7, 2020

This work is licensed under a Creative Commons Attribution 4.0 International License.

Isolation and Characterization of Bioactive Anti-inflammatory Flavonoids from Arisaema tortuosum Tubers

https://doi.org/10.14233/ajchem.2020.22895

Priyanka Chakraborty

BCDA College of Pharmacy & Technology, Hridaypur, Barasat-700127, India

Kamalika Mazumder

BCDA College of Pharmacy & Technology, Hridaypur, Barasat-700127, India

Nripendra Nath Bala

BCDA College of Pharmacy & Technology, Hridaypur, Barasat-700127, India

Sudipta Das

Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia-741222, India

Corresponding Author(s) : Priyanka Chakraborty

priyanka290986@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020
Article Published : December 7, 2020

Abstract

Present study was focused on the isolation and characterization of the anti-inflammatory compound(s) from the methanolic extracts of Arisaema tortuosum tuber by column chromatography, TLC, FT-IR, ¹H, ¹³C NMR and HR-MS. Among all the fractions obtained A. tortuosum fraction 3 (PC-1) and fraction 5 (PC-2) showed significant in vivo anti-inflammatory activity. This study endorsed that the isolated bioactive compound PC-2 showed better anti-inflammatory activity at a dose of 25 mg/Kg BW. The results indicate that PC-2 and PC-1 methanolic extract of A. tortuosum tuber may be competing for the tent in the therapy of inflammatory ailments.

Keywords

Arisaema tortuosum Anti-inflammatory Flavonoids

Chakraborty, P., Mazumder, K., Nath Bala, N., & Das, S. (2020). Isolation and Characterization of Bioactive Anti-inflammatory Flavonoids from Arisaema tortuosum Tubers. Asian Journal of Chemistry, 32(12), 3093–3096. https://doi.org/10.14233/ajchem.2020.22895

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References

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References

H. Verma, V.K. Lal, K.K. Pant and N. Soni, Int. J. Adv. Pharm. Biol. Chem., 1, 176 (2012).

K.K. Gangwar, Deepali and R.S. Gangwar, Nat. Sci., 8, 66 (2010).

N.P. Balami, Tribhuvan Univ. J., 24, 13 (1970); https://doi.org/10.3126/tuj.v24i1.251

S.B. Padal, P.P. Murty, D.S. Rao and M. Venkaiah, J. Phytol., 2, 70 (2010).

K. Choudhary, M. Singh and U. Pillai, Am.-Eur. J. Bot., 1, 38 (2008).

V. Dhuna, J.S. Bains, S.S. Kamboj, J. Singh and A.K. Saxena, J. Biochem. Mol. Biol., 38, 526 (2005).

P. Kumari, G.C. Joshi and L.M. Tewari, Int. J. Biodivers. Conserv., 3, 298 (2011).

J. Krych and L. Gebicka, Int. J. Biol. Macromol., 58, 148 (2013); https://doi.org/10.1016/j.ijbiomac.2013.03.070

F.A. Ragab, T.A.A. Yahya, M.M. El-Naa and R.K. Arafa, Eur. J. Med. Chem., 82, 506 (2014); https://doi.org/10.1016/j.ejmech.2014.06.007

S.-S. Tian, F.-S. Jiang, K. Zhang, X.-X. Zhu, B. Jin, J.-J. Lu and Z.-S. Ding, Fitoterapia, 92, 34 (2014); https://doi.org/10.1016/j.fitote.2013.09.016

X. Zhang, H. Huang, X. Zhao, Q. Lv, C. Sun, X. Li and K. Chen, J. Funct. Foods, 14, 144 (2015); https://doi.org/10.1016/j.jff.2015.01.030

Y. Wang, S. Chen and O. Yu, Appl. Microbiol. Biotechnol., 91, 949 (2011); https://doi.org/10.1007/s00253-011-3449-2

C. Rakers, S.M. Schwerdtfeger, J. Mortier, S. Duwe, T. Wolff, G. Wolber and M.F. Melzig, Bioorg. Med. Chem. Lett., 24, 4312 (2014); https://doi.org/10.1016/j.bmcl.2014.07.010

C. Giuliani, I. Bucci, S. Di Santo, C. Rossi, A. Grassadonia, M. Piantelli, F. Monaco and G. Napolitano, Food Chem. Toxicol., 66, 23 (2014); https://doi.org/10.1016/j.fct.2014.01.016

H. Isoda, H. Motojima, S. Onaga, I. Samet, M.O. Villareal and J. Han, Chem. Biol. Interact., 220, 269 (2014); https://doi.org/10.1016/j.cbi.2014.07.006

H. Verma, V.K. Lal and K.K. Pant, J. Pharm. Res., 9, 60 (2015).

N.N. Azwanida, Med. Aromat. Plants, 4, 196 (2015); https://doi.org/10.4172/2167-0412.1000196

A. Altemimi, N. Lakhssassi, A. Lakhssassi, D.G. Watson and D.A. Lightfoot, Plants, 6, 42 (2017); https://doi.org/10.3390/plants6040042

T. Hilagavathi, R. Arvindganth, D. Vidhya and R. Dhivya, Res. J. Pharm., 6, 246 (2015).

A. Guzel, H. Aksit, M. Elmastas, R. Erenler, Phcog. Mag., 13, 316 (2017); https://doi.org/10.4103/0973-1296.204556

A. Sarkar, V.D. Tripathi and R.K. Sahu, Clin. Exp. Pharmacol., 7, 1 (2017).

S. Das, P.K. Halder, G. Pramanik, S.P. Panda and S. Bera, Afr. J. Tradit. Complement Altern. Med., 8, 11 (2011).

C.K. Karayildirim, Celal Bayar Univ. J. Sci., 13, 943 (2017).

V.K. Chaudhri, Z. Hussain, A. Pandey, R. Khan and A.K. Srivastava, Int. J. Res. Pharm. Sci., 6, 15 (2016).

Issue

Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

Isolation and Characterization of Bioactive Anti-inflammatory Flavonoids from Arisaema tortuosum Tubers

Corresponding Author(s) : Priyanka Chakraborty

Abstract

Keywords

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