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Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

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Ammonium Chloride: An Efficient and Environmentally benign Catalyst for Knoevenagel Condensation of Carbonyl and Active Methylene Compounds

https://doi.org/10.14233/ajchem.2020.22879
S. Tasqeeruddin
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
Yahya I. Asiri
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
M. Mujahid Alam
Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia

Corresponding Author(s) : S. Tasqeeruddin

drsyedtasqeeruddin@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

Abstract

In the present study, a rapid, simple and an efficient procedure for the Knoevenagel condensation of various carbonyl and active methylene compounds in ethanol at a moderate temperature in the presence of a catalytic amount of an efficient, environmentally benign and inexpensive ammonium chloride is reported. Simple reaction procedure, economic and ecofriendly catalyst, mild reaction conditions and good to excellent yield of the products are the characteristic features of this study. The non-extractive workup/purification, economic and environmentally benign catalyst make this operationally straightforward procedure affordable for large scale.

Keywords

Active methylene Ammonium chloride catalyst Knoevenagel condensation
Tasqeeruddin, S., I. Asiri, Y., & Mujahid Alam, M. (2020). Ammonium Chloride: An Efficient and Environmentally benign Catalyst for Knoevenagel Condensation of Carbonyl and Active Methylene Compounds. Asian Journal of Chemistry, 32(12), 3024–3028. https://doi.org/10.14233/ajchem.2020.22879
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