Issue

Vol. 32 No. 11 (2020): Vol 32 Issue 11

Copyright (c) 2020 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Design, Synthesis, Characterization and Biological Activities of Recent Isatin Derivatives with Proven Pharmacophoric Moiety

https://doi.org/10.14233/ajchem.2020.22823
Ruchi Bhatnagar
Department of Chemistry, Amity University, Lucknow Campus, Lucknow-226028, India
Jaya Pandey
Department of Chemistry, Amity University, Lucknow Campus, Lucknow-226028, India
Deepa Panhekar
Department of Chemistry, Dr. Ambedkar College, Deekshaboomi, Nagpur-440008, India

Corresponding Author(s) : Ruchi Bhatnagar

ruchibhatnagar2020@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 11 (2020): Vol 32 Issue 11

Abstract

Isatin derivatives, alkylated with proven pharmacophoric moiety were synthesized for various biodynamic activities. To enhance some biodynamic properties like antibacterial and antifungal, imine formation with various compounds at C3 was analyzed. The isatin derivatives were characterized and examined for various biodynamic activities on bacteria, fungus and cancer cell lines.

Keywords

Isatin Schiff base Biological activity
Bhatnagar, R., Pandey, J., & Panhekar, D. (2020). Design, Synthesis, Characterization and Biological Activities of Recent Isatin Derivatives with Proven Pharmacophoric Moiety. Asian Journal of Chemistry, 32(11), 2731–2738. https://doi.org/10.14233/ajchem.2020.22823
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. J.F.M. da Silva, S.J. Garden and A.C. Pinto, J. Braz. Chem. Soc., 12, 273 (2001); https://doi.org/10.1590/S0103-50532001000300002
  2. G. Chen, X.J. Hao, Q.Y. Sun and J. Ding, Chem. Pap., 64, 673 (2010).
  3. G. Chen, H.P. He, J. Ding and X.J. Hao, Heterocycl. Commun., 15, 355 (2009); https://doi.org/10.1515/HC.2009.15.5.355
  4. G. Chen, J. Yang, S. Gao, H.P. He, S.L. Li, Y.T. Di, Y. Chang, Y. Lu and X.J. Hao, Mol. Divers., 16, 151 (2012); https://doi.org/10.1007/s11030-011-9342-1
  5. G. Chen, Y. Tang, J. Zhang, Y. Wu, X.-J. Hao and S.-Z. Mu, Lett. Org. Chem., 8, 614 (2011); https://doi.org/10.2174/157017811799304269
  6. Varun, Sonam and R. Kakkar, Medchemcomm, 10, 351 (2019); https://doi.org/10.1039/c8md00585k
  7. S.N. Pandeya, S. Smitha and J.P. Stables, Arch. Pharm. Med. Chem., 335, 129 (2002); https://doi.org/10.1002/1521-4184(200204)335:4<129::AID-ARDP129>3.0.CO;2-W
  8. S.N. Pandeya, D. Sriram, P. Yogeeswari and S. Ananthan, Chemotherapy, 47, 266 (2001); https://doi.org/10.1159/000048533
  9. T.D. Brewerton, J.J. Zealberg, R.B. Lydiard, V. Glover, M. Sandler and J.C. Ballenger, Biol. Psychiatry, 37, 481 (1995); https://doi.org/10.1016/0006-3223(94)00328-Z
  10. K.L. Vine, J.M. Locke, M. Ranson, S.G. Pyne and J.B. Bremner, Bioorg. Med. Chem., 15, 931 (2007); https://doi.org/10.1016/j.bmc.2006.10.035
  11. K.L. Vine, L. Matesic, J.M. Locke and D. Skropeta, ed.: M. Prudhomme, Recent Highlights in the Development of Isatin-Based Anticancer Agents. In: Advances in Anticancer Agents in Medicinal Chemistry, Bentham Science Publishers: Sharjah, UAE, pp. 254-312 (2013).
  12. J.T. Nguyen and J.A. Wells, Proc. Natl. Acad. Sci. USA, 100, 7533 (2003); https://doi.org/10.1073/pnas.1031631100
  13. Y. Liu, H.A. Lashuel, S. Choi, X. Xing, A. Case, J. Ni, L.A. Yeh, G.D. Cuny, R.L. Stein and P.T. Lansbury Jr., Chem. Biol., 10, 837 (2003); https://doi.org/10.1016/j.chembiol.2003.08.010
  14. G. Bacher, B. Nickel, P. Emig, U. Vanhoefer, S. Seeber, A. Shandra, T. Klenner and T. Beckers, Cancer Res., 61, 392 (2001).
  15. K.L. Vine, J.M. Locke, M. Ranson, S.G. Pyne and J.B. Bremner, J. Med. Chem., 50, 5109 (2007); https://doi.org/10.1021/jm0704189
  16. K.L. Vine, L. Matesic, J.M. Locke, M. Ranson and D. Skropeta, Anticancer. Agents Med. Chem., 9, 397 (2009); https://doi.org/10.2174/1871520610909040397
  17. L. Matesic, J.M. Locke, J.B. Bremner, S.G. Pyne, D. Skropeta, M. Ranson and K.L. Vine, Bioorg. Med. Chem., 16, 3118 (2008); https://doi.org/10.1016/j.bmc.2007.12.026
  18. N.R. Modi, R.J. Shah, M.J. Patel, M. Suthar, B.F. Chauhan and L.J. Patel, Med. Chem. Res., 20, 615 (2011); https://doi.org/10.1007/s00044-010-9361-y
  19. P. Singh, S. Kaur, V. Kumar, P.M. Bedi, M.P. Mahajan, I. Sehar, H.C. Pal and A.K. Saxena, Bioorg. Med. Chem. Lett., 21, 3017 (2011); https://doi.org/10.1016/j.bmcl.2011.03.043
  20. A.H. Abadi, S.M. Abou-Seri, D.E. Abdel-Rahman, C. Klein, O. Lozach and L. Meijer, Eur. J. Med. Chem., 41, 296 (2006); https://doi.org/10.1016/j.ejmech.2005.12.004
  21. R. Gudipati, R.N.R. Anreddy and S. Manda, Saudi Pharm. J., 19, 153 (2011); https://doi.org/10.1016/j.jsps.2011.03.002
  22. L. Matesic, J.M. Locke, K.L. Vine, M. Ranson, J.B. Bremner and D. Skropeta, Bioorg. Med. Chem., 19, 1771 (2011); https://doi.org/10.1016/j.bmc.2011.01.015
  23. A. El-Faham, M. Farooq, S.N. Khattab, N. Abutaha, M.A. Wadaan, H.A. Ghabbour and H.-K. Fun, Molecules, 20, 14638 (2015); https://doi.org/10.3390/molecules200814638
  24. G. Cerchiaro, K. Aquilano, G. Filomeni, G. Rotilio, M.R. Ciriolo and A.M.D.C. Ferreira, J. Inorg. Biochem., 99, 1433 (2005); https://doi.org/10.1016/j.jinorgbio.2005.03.013
  25. S.K. Sridhar, M. Saravanan and A. Ramesh, Eur. J. Med. Chem., 36, 615 (2001); https://doi.org/10.1016/S0223-5234(01)01255-7
  26. G. Chen, Y. Wang, H.P. He, S.L. Li, L.G. Zhou and X.J. Hao, Acta Botany Yunnan, 29, 712 (2007) (In Chinese).
  27. O. Trott and A.J. Olson, J. Comput. Chem., 31, 455 (2010); https://doi.org/10.1002/jcc.21334
  28. C.D. Buchman and T.D. Hurley, J. Med. Chem., 60, 2439 (2017); https://doi.org/10.1021/acs.jmedchem.6b01825
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0