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Vol. 32 No. 11 (2020): Vol 32 Issue 11

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Synthesis, Spectral, Electrochemical, Antimicrobial and DNA Binding/Cleavage Studies of Metal Complexes with Schiff Base of Fluoro Substituted Aniline

https://doi.org/10.14233/ajchem.2020.22876
G. Saraswathy
P.G. and Research Centre of Chemistry, Jayaraj Annapackiam College for Women, Periyakulam-625601, India
M. Sankarganesh
Department of Chemistry, K. Ramakrishnan College of Technology, Samayapuram, Tiruchirappalli-621112, India
C. Anitha
Department of Chemistry, The M.D.T. Hindu College (Affiliated to Manonmaniam Sundaranar University, Tirunelveli-627010, India
M. Kalanithi
P.G. and Research Centre of Chemistry, Jayaraj Annapackiam College for Women, Periyakulam-625601, India

Corresponding Author(s) : M. Kalanithi

kalacharle@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 11 (2020): Vol 32 Issue 11

Abstract

A new series of Schiff base complexes of transition (Fe3+, Co2+, Ni2+, Cu2+ and Zn2+) metal were synthesized from 4-fluoroaniline and 2-thiophene carboxaldehyde and structurally characterized by spectroscopic techniques. The Schiff base is found to be a bidentate ligand and coordinates to the metal ion through azomethine nitrogen and sulphur atom of the thiophene ring. In fluorescence studies, an interaction of Ca2+ and Mg2+ ions with the ligand was also studied. The Schiff base and its transition metal complexes showed inhibition activity against Gram-positive bacteria (Staphylococcus aureus, Escherichia coli), Gram-negative bacteria (Pseudomonas aeruginosa) and antifungal activity against Candida albicans. Electrochemical redox reactions of the metal complexes were analyzed by cyclic voltammetry. The DNA binding properties of the complexes with HS-DNA have been explored by electron absorption spectroscopy. The cleavage reaction of the synthesized ligand and its metal complexes was monitored by gel-electrophoresis method. The nuclease activity of the above metal(II) complexes shows that the Cu(II) complex can cleave DNA effectively than ligand and other metal complexes.

Keywords

2-Thiophene carboxaldehyde 4-Fluoroaniline Schiff base DNA Binding studies Antimicrobial activity
Saraswathy, G., Sankarganesh, M., Anitha, C., & Kalanithi, M. (2020). Synthesis, Spectral, Electrochemical, Antimicrobial and DNA Binding/Cleavage Studies of Metal Complexes with Schiff Base of Fluoro Substituted Aniline. Asian Journal of Chemistry, 32(11), 2911–2916. https://doi.org/10.14233/ajchem.2020.22876
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