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Vol. 32 No. 10 (2020): Vol 32 Issue 10

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Zirconium(IV) Oxychloride: A Simple and Efficient Catalyst for the Synthesis of Chromen-2-one Derivatives

https://doi.org/10.14233/ajchem.2020.22849
S. Tasqeeruddin
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
Yahya I. Asiri
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
S. Shaheen
Anwarul Uloom College of Pharmacy, Mallepally, Hyderabad-500001, India

Corresponding Author(s) : S. Tasqeeruddin

drsyedtasqeeruddin@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 10 (2020): Vol 32 Issue 10

Abstract

The present work explores a highly efficient, environmental friendly, green protocol for the synthesis of chromen-2-one derivatives (3a-m) by the condensation of salicylaldehydes with various active methylene compounds using zirconium(IV) oxychloride as catalyst. This is a convenient and rapid method for Knoevenagel condensation and this methodology offers several advantages including shorter reaction time, milder conditions, inexpensive catalyst, simple operational procedure and allowed to achieve the desired products in excellent yields. The structures of all the synthesized compounds were confirmed by spectral data.

Keywords

Zirconium (IV) oxychloride Chromen-2-one derivatives Salicylaldehydes Active methylene compounds
Tasqeeruddin, S., I. Asiri, Y., & Shaheen, S. (2020). Zirconium(IV) Oxychloride: A Simple and Efficient Catalyst for the Synthesis of Chromen-2-one Derivatives. Asian Journal of Chemistry, 32(10), 2611–2616. https://doi.org/10.14233/ajchem.2020.22849
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