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Vol. 32 No. 10 (2020): Vol 32 Issue 10

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An Efficient Synthesis of Thiophene Conjugated Benzothiazepines: in vitro Screening for their Antimicrobial Activity

https://doi.org/10.14233/ajchem.2020.22861
K.R. Raghavendra
Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru-570006, India ; Department of Chemistry, S.B.R.R. Mahajana College, Mysuru-570012, India
P. Sudeep
Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru-570006, India
K. Ajay Kumar
Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru-570006, India
H.P. Jayadevappa
Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru-570006, India

Corresponding Author(s) : H.P. Jayadevappa

hpjayadevappa@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 10 (2020): Vol 32 Issue 10

Abstract

A series of novel thiophene conjugated benzothiazepines were synthesized by the reaction of chalcones with 2-aminobenzenethiol in citrus juice medium. The new compounds were characterized by spectroscopic studies. Results of in vitro antimicrobial evaluation of newly synthesized compounds 5a-j shows that the compounds 5a and 5c have excellent antimicrobial inhibition in the range of 12.5-25.0 μg/mL against bacteria S. aureus, E. coli, P. aeruginosa and fungi A. niger, A. flavus organisms comparable to ciprofloxacin and nystatin and therefore these compounds might acts as lead molecules as antimicrobial agents.

Keywords

2-Aminobenzenethiol Thiophene Benzothiazepines Chalcone Antibacterial activity Antifungal activity
Raghavendra, K., Sudeep, P., Ajay Kumar, K., & Jayadevappa, H. (2020). An Efficient Synthesis of Thiophene Conjugated Benzothiazepines: in vitro Screening for their Antimicrobial Activity. Asian Journal of Chemistry, 32(10), 2601–2605. https://doi.org/10.14233/ajchem.2020.22861
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