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Vol. 32 No. 10 (2020): Vol 32 Issue 10

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Complexes of Pyrimidine Thiones: Mechanochemical Synthesis and Biological Evaluation

https://doi.org/10.14233/ajchem.2020.22813
Pooja Sethi
Department of Chemistry, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala-133207, India
Rajshree Khare
Principal, M.P.N. College, Mullana, Ambala-133207, India
Renuka Choudhary
Department of Biotechnology, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala-133207, India

Corresponding Author(s) : Pooja Sethi

pooja.amb80@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 10 (2020): Vol 32 Issue 10

Abstract

A new series of metal complexes with 1-(2-methylphenyl)-4,4,6-trimethyl pyrimidine-2-thione (2-HL1) and 1-(4-methylphenyl)-4,4,6-trimethyl pyrimidine-2-thione (4-HL2) ligands, [M(mppt)2(H2O)n] (M(II) = Cu, Mn, Co; n = 2 and M(II) = Ni, Zn; n = 0) have been synthesized using mechanochemical protocol. The complexes have been framed as [M(mppt)2(H2O)n] due to 1:2 (metal:ligand) nature of these metal complexs. Structures have been further confirmed on the basis of elemental analysis, Magnetic susceptibility measurements, electronic, infrared, far infrared, proton NMR, Mass spectral moment and thermogravimetric analysis studies. The infrared spectral data suggested that ligand behaves as a bidentate, coordinating through – N (endocyclic) and – S (exocyclic) donor atoms. All the compounds have also been screened for antibacterial and DNA photocleavage potential. Ligands complexed with Mn and Ni metals have shown the effect of substitution on their biological potentials. It was found that substitution at 4th or para position makes the ligand and its metal complexes have better antibacterial and DNA photocleaving agents.

Keywords

DNA photocleavage Pyrimidine-2-thione Mechanochemical protocol
Sethi, P., Khare, R., & Choudhary, R. (2020). Complexes of Pyrimidine Thiones: Mechanochemical Synthesis and Biological Evaluation. Asian Journal of Chemistry, 32(10), 2594–2600. https://doi.org/10.14233/ajchem.2020.22813
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