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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 Amulya Sinha

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Glucose Coated Nano Fe3O4 (Glu@Fe3O4): A Potential Organocatalyst for Synthesis of 4,7-Dihydro-2H-pyrazolo[3,4-b]pyridines in Ethanol

https://doi.org/10.14233/ajchem.2025.32988
Amulya Sinha
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0009-0003-6057-6423
Arzoo Siddiqui
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0009-0004-5305-2418
Vaibhav Tripathi
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0009-0009-5217-9288
Girish Singh
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0009-0001-9753-2622
Amit Yadav
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
Rudraksh Srivastava
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0000-0001-9093-2773
Nikhat Fatima
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0009-0002-3542-6784
Gautam Kumar
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0009-0009-8165-6653
Vivek Bhadauria
Green Laboratory, Department of Chemistry, Ewing Christian College, University of Allahabad, Prayagraj-211003, India
https://orcid.org/0000-0003-1254-3734

Corresponding Author(s) : Vivek Bhadauria

bvivek17@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

Two novel homologous series of target moieties, pyrazolo[3,4-b]pyridine-5-carboxylate substitutes (4a-e) as well as pyrazolo[3,4-b]pyridine-5-carbonitrile substitutes (5a-g) involving heterocyclic scaffold have been synthesized and characterized using FT-IR, NMR and MS spectrometry to ascertain the molecular structure. The synthetic procedure has been carried out by a one-pot three-constituent mechanistic pathway of pyrazol-3-amine, several aromatic aldehydes as well as selected CH-active compounds under green conditions via one-pot process in the presence of glucose coated nano Fe3O4 (Glu@Fe3O4) as an organocatalyst and ethanol as an efficient solvent. This conversion is congenial with a wide heterogeneity of functional group endurance. The optimized reaction conditions, good output, incorporation of organocatalyst, no necessity for column chromatographic procedure, economical and eco-friendly solvent are the merits of this reaction protocol. An ecofriendly, harmless, diversified, excellent paramagnetic behaviour possessing catalyst (Glu@Fe3O4) was prepared and characterization was performed incorporating Fourier transform infrared spectroscopy, as well as X-ray diffraction technique. The surface of magnetic nanoparticles enveloped with glucose imparted magnificent catalytic property. The catalyst could be reprocessed and reutilized until six rounds unaccompanied by major downfall in the catalytic efficiency.

Keywords

Pyrazolo[3,4-b]pyridine Multicomponent reactions Green catalyst Magnetic nanoparticles
Sinha, A., Siddiqui, A., Tripathi, V., Singh, G., Yadav, A., Srivastava, R., … Bhadauria, V. (2025). Glucose Coated Nano Fe3O4 (Glu@Fe3O4): A Potential Organocatalyst for Synthesis of 4,7-Dihydro-2H-pyrazolo[3,4-b]pyridines in Ethanol. Asian Journal of Chemistry, 37(2), 300–308. https://doi.org/10.14233/ajchem.2025.32988
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