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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 Baliram Vibhute

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In vitro Antibacterial, Antifungal, Cytotoxicity and Molecular Docking Studies of Transition Metal(II) Complexes Derived from New Quinoline Schiff Base

https://doi.org/10.14233/ajchem.2025.32957
Baliram Tukaram Vibhute
Department of Chemistry, Doshi Vakil Arts and G.C.U.B. Science & Commerce College, Goregaon-402103, India
https://orcid.org/0000-0002-0022-9775
Amol Jagannath Ghoti
Department of Chemistry, Doshi Vakil Arts and G.C.U.B. Science & Commerce College, Goregaon-402103, India
https://orcid.org/0000-0002-6159-2893

Corresponding Author(s) : Baliram Tukaram Vibhute

vbtchem@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

The synthesis of new quinoline based Schiff base and its metal complexes viz. Co2+, Cu2+, Ni2+ & Cd2+, were synthesized and characterized. The Schiff base was prepared by condensation of 2-hydroxy-7-methoxyquinoline-3-carbaldehyde and p-methylbenzene sulfonohydrazide. The structure of Schiff base and its metal(II) complexes were characterized through different physical and analytical techniques i.e., FTIR, 1H NMR, 13C NMR, ESR, ESI-MS, electronic spectra, elemental analysis and TGA. Magnetic susceptibility values indicate that Cu(II), Co(II) and Ni(II) complexes were paramagnetic in nature. Low molar conductivity values reveal that all the metal complexes are non-electrolytic in nature. Furthermore, all the compounds were subjected to in vitro biological activity and computational docking studies. The results showed that the Schiff based ligand and its metal(II) complexes exhibited higher activity against the A-549 cancer cell line and lower in case of the MCF-7 cancer cell lines compared to standard drug paclitaxel. Furthermore, the molecular docking study shows the significant binding affinity of metal complexes with tubulin protein. Hence, all the synthesized Schiff base metal complexes have excellent biological activity and could be act as potential anticancer agents.

Keywords

Quinoline Schiff base Metal(II) complexes Biological activity Molecular docking Cytotoxicity
Vibhute, B. T., & Ghoti, A. J. (2025). In vitro Antibacterial, Antifungal, Cytotoxicity and Molecular Docking Studies of Transition Metal(II) Complexes Derived from New Quinoline Schiff Base. Asian Journal of Chemistry, 37(2), 266–274. https://doi.org/10.14233/ajchem.2025.32957
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