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Vol. 37 No. 1 (2025): Vol 37 Issue 1, 2025

Copyright (c) 2024 Begum Alia, Farveen MD, Sreelatha G

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Design and Synthesis of Quinazoline Bearing Thiazolotriazole Scaffolds as Potent EGFR Inhibitor for Anti-Breast Cancer Activity

https://doi.org/10.14233/ajchem.2025.32748
MD Farveen
Department of Chemistry, Osmania University, Hyderabad-500007, India
https://orcid.org/0009-0005-5550-346X
G. Sreelatha
Department of Chemistry, Osmania University, Hyderabad-500007, India
https://orcid.org/0009-0009-2768-5621
Alia Begum
Department of Chemistry, Telangana Mahila Viswavidyalayam, Koti, Hyderabad-500095, India
https://orcid.org/0000-0001-6755-9413

Corresponding Author(s) : Alia Begum

alia78ou@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 1 (2025): Vol 37 Issue 1, 2025

Abstract

A number of fused heterocyclic hybrids with central rings of thiazolotriazoles are synthesized and characterized by 1H NMR, 13C NMR and EI-MS techniques. The synthesized compounds showed variable degrees of efficacy in their in vitro cytotoxic activity against MCF-7, MDA-MB-231 and MCF-10A cell lines. Remarkably some analogues exhibited greater activity than the reference drugs, erlotinib. The most effective compounds, 6i, 6h and 6j, displayed significant EGFR tyrosine kinase inhibition and significant cytotoxicity, in accordance with the molecular docking investigations that revealed favourable binding contacts and energies inside the EGFR active region.

Keywords

Quinazoline Thiazolotriazole Breast cancer EGFR inhibitor Molecular docking
Farveen, M., Sreelatha, G., & Begum, A. (2024). Design and Synthesis of Quinazoline Bearing Thiazolotriazole Scaffolds as Potent EGFR Inhibitor for Anti-Breast Cancer Activity. Asian Journal of Chemistry, 37(1), 1–9. https://doi.org/10.14233/ajchem.2025.32748
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