Copyright (c) 2024 Kanti Ranjan Nath Bhowmik Kanti
This work is licensed under a Creative Commons Attribution 4.0 International License.
Biomedical Applications of Some Schiff Bases and Their Transition Metal Complexes: A Review
Corresponding Author(s) : K.R. Nath Bhowmik
Asian Journal of Chemistry,
Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024
Abstract
A diverse class of compounds known as Schiff bases and their metal complexes are synthesized via condensation of amino and carbonyl compounds. Schiff bases and their metal complexes have several applications in analytical, pharmacological, organic, bioinorganic, and material research, which has increased interest in this class of molecule. In a variety of reactions, even in the presence of moisture, many Schiff base metal complexes have outstanding catalytic activity. Schiff bases serve as versatile pharmacophores due to their ability to bind with metals of different oxidation states to form complexes. Over the past few decades of metal-based drug research, Schiff base metal complexes have been the focus of much coordination chemistry research due to their utility across multiple scientific scenarios. As therapeutic agents, they may be beneficial in numerous circumstances, including infections, tumors, viruses, inflammation, pain and fungus. The focus of medicinal chemists is currently on the development of novel chemotherapeutic Schiff bases and their metal complexes. This review summarizes some of the most promising antimicrobial and anticancer activities of Schiff bases and their transition metal complexes. A possible relationship between structure and activity in some cases is also discussed.
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