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Vol. 36 No. 9 (2024): Vol 36 Issue 9, 2024

Copyright (c) 2024 B.V. Durgarao, D.V.L. Sirisha, K. Apparao, V. Narasingrao, K. Balageeta, N. Krishna Rao

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An Efficient One Pot Synthesis and Biological Activities of 6H-Indolo[2,3-b]quinoxalines Promoted by Palladium Acetate as Catalyst

https://doi.org/10.14233/ajchem.2024.31782
B.V. Durgarao
Department of DFS (Chemistry), Oil & Natural Gas Corporation (ONGC), Rajamahendravaram-533106, India
https://orcid.org/0009-0007-0048-4817
D.V.L. Sirisha
Department of Organic Chemistry & Biochemistry, PRISM PG & DG College, Visakhapatnam-530016, India
https://orcid.org/0009-0008-7298-7314
K. Apparao
Department of Chemistry, Dr. B.R. Ambedkar University, Srikakulam-532410, India
https://orcid.org/0009-0006-6461-7503
V. Narasingrao
Department of Organic Chemistry & Biochemistry, PRISM PG & DG College, Visakhapatnam-530016, India
K. Balageeta
Department of Engineering Chemistry, Sagi Rama Krishnam Raju Engineering College, Bhimavaram-534204, India
https://orcid.org/0009-0004-3332-7461
N. Krishna Rao
Department of Organic Chemistry & Biochemistry, PRISM PG & DG College, Visakhapatnam-530016, India
https://orcid.org/0000-0002-7719-9930

Corresponding Author(s) : N. Krishna Rao

naallakrishnarao@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 9 (2024): Vol 36 Issue 9, 2024

Abstract

A multi-component one pot protocol for the synthesis of quinoxalines derivatives by condensation reaction of substituted isatin with substituted o-phenylene diamine in presence palladium acetate as catalyst in strong base such as triphenylphosphine under conventional method has been reported. The molecular structures of the newly synthesized compounds were characterized by elemental analyses, IR, 1H NMR, 13C NMR and LCMS spectral data. The presented method is mild, inexpensive, highly atom economy and easy work up to give the products in good to excellent yields. All the synthesized compounds were also evaluated for in vitro antibacterial assay against Gram-negative (Escherichia coli and Staphylococcus aureus), Gram-positive (Salmonella typhi and Bacillus subtilis) and fungi (Aspergillus niger and Candida albicans) pathogenic bacteria in comparison to the standards streptomycin and fluconazole.

Keywords

Substituted isatin 6H-Indolo[2,3-b]quinoxalines Palladium acetate Biological activity
Durgarao, B., Sirisha, D., Apparao, K., Narasingrao, V., Balageeta, K., & Rao, N. K. (2024). An Efficient One Pot Synthesis and Biological Activities of 6H-Indolo[2,3-b]quinoxalines Promoted by Palladium Acetate as Catalyst. Asian Journal of Chemistry, 36(9), 2001–2005. https://doi.org/10.14233/ajchem.2024.31782
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