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Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Copyright (c) 2024 Nagaraju Myakala, Kotaiah Kandula, Nagamani Rayala, Sateesh Kuna, Vishnu Thumma, A.K.D. Bhavani

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Design and Synthesis of Novel Quinazolin-4(3H)-One Appended 1,2,4-Oxadiazoles as Antimicrobial Agents

https://doi.org/10.14233/ajchem.2024.31907
Nagaraju Myakala
Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, India
https://orcid.org/0000-0002-2479-8921
Kotaiah Kandula
Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, India
https://orcid.org/0000-0002-4601-8463
Nagamani Rayala
Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, India
https://orcid.org/0000-0002-8148-0530
Sateesh Kuna
Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, India
https://orcid.org/0000-0001-5979-9740
Vishnu Thumma
Department of Sciences and Humanities, Matrusri Engineering College, Hyderabad-500059, India
https://orcid.org/0000-0001-6830-3671
A.K.D. Bhavani
Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, India
https://orcid.org/0000-0002-5493-0663

Corresponding Author(s) : A.K.D. Bhavani

durgabhavani237@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Abstract

A novel series of hybrid heterocycles having quinazolinone based 1,2,4-oxadiazoles scaffold with methylamino linkage were obtained in two synthetic pathways. In method I, quinazolinone based ester reacted with amidoximes and gave the corresponding hybrid products in poor yields. To reduce the duration of reaction time and increase the yields of the products, dehydrochlorination reaction of 6-aminoquinazolinone was carried out with 5-chloromethyl-1,2,4-oxadiazoles in other synthetic method, which furnished the products in good to excellent yields. The synthesized 1,2,4-oxadiazole hybrids were characterized using spectroscopic techniques and also screened for their antimicrobial activity against bacteria and fungi, among which chloro-substituted analogues 6d and 6e presented potent activity against all strains whereas other analogues proven to have moderate activities.

Keywords

Aminoquinazolinone Quinazolinonylglycinate Amidoximes 1,2,4-Oxadiazoles Antimicrobial activity
Myakala, N., Kandula, K., Rayala, N., Kuna, S., Thumma, V., & Bhavani, A. (2024). Design and Synthesis of Novel Quinazolin-4(3H)-One Appended 1,2,4-Oxadiazoles as Antimicrobial Agents. Asian Journal of Chemistry, 36(8), 1972–1976. https://doi.org/10.14233/ajchem.2024.31907
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