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Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Copyright (c) 2024 Ketan Vashisht, Pooja Sethi, Anshul Bansal, Hardeep Singh Tuli, Ammar Abdulrahman Jairoun, Moyad Shahwan, Seema Ramniwas, Ritu Chauhan

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

https://doi.org/10.14233/ajchem.2024.31652
Ketan Vashisht
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, India
Pooja Sethi
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, India
https://orcid.org/0000-0002-4200-1883
Anshul Bansal
Department of Chemistry, S.A. Jain College, Ambala City-134003, India
Hardeep Singh Tuli
Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, India
https://orcid.org/0000-0003-1155-0094
Ammar Abdulrahman Jairoun
Health and Safety Department, Dubai Municipality, Dubai 67, Dubai, United Arab Emirates; Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Pulau Pinang, 11500, Malaysia
https://orcid.org/0000-0002-4471-0878
Moyad Shahwan
Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates; Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates
https://orcid.org/0000-0001-8367-4841
Seema Ramniwas
University Centre for Research & Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali-140413, India
Ritu Chauhan
Department of Biotechnology, Graphic Era Deemed to be University, Dehradun-248002, India
https://orcid.org/0000-0002-9056-6619

Corresponding Author(s) : Pooja Sethi

pooja.amb80@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Abstract

Pyrazoles, a class of heterocyclic compounds, have garnered considerable attention in drug development due to their intriguing properties, particularly those containing a pyrazole moiety. Pyrazole, a pivotal chemical in the creation of potent bioactive agents, encompasses five heterocyclic members. The discovery of certain pyrazole compounds exhibiting robust biological activities has spurred interest in this field of inquiry. Heterocyclic compounds incorporating nitrogen and its derivatives have historically served as crucial sources of medicinal compounds. Given that the heterocyclic group constitutes a vast reservoir of organic molecules, its significance in both theoretical and applied chemistry has grown significantly. Extensive literature indicates that researchers have employed diverse synthetic strategies in recent years to produce substituted pyrazole derivatives with promising biological potential as anti-HIV, anti-inflammatory, antitumor and antimicrobial agents. Inflammation, a multifaceted biological response essential for the body’s defense mechanisms, can also contribute to various pathological conditions when dysregulated. Understanding the underlying molecular mechanisms offers a foundation for targeted interventions against inflammatory disorders. These insights fuel ongoing endeavors to discover effective and innovative anti-inflammatory agents with potential therapeutic applications. This review delves into the synthesis and characterization of various pyrazole derivatives, emphasizing structural modifications influencing their anti-inflammatory efficacy. The insights provided herein are invaluable for the rational design and synthesis of novel anti-inflammatory agents. Furthermore, the review concludes with a discussion on future perspectives, underscoring the imperative for further research to optimize the therapeutic potential of pyrazole derivatives as anti-inflammatory agents.

Keywords

Pyrazole Anti-inflammatory antitumor Anti-HIV Antimicrobial agents
Vashisht, K., Sethi, P., Bansal, A., Tuli, H. S., Jairoun, A. A., Shahwan, M., … Chauhan, R. (2024). Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review. Asian Journal of Chemistry, 36(6), 1217–1231. https://doi.org/10.14233/ajchem.2024.31652
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