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Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Copyright (c) 2024 Om Prakash Joshi, Ankit Kumar Dash, Ramalingam Thirumoorthi, Chandrakanta Dash

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Iron-Catalyzed Annulation of 2-Aminobenzaldehydes with Iodonium Ylides: A Mild and General Route for the Synthesis of Acridinone Derivatives

https://doi.org/10.14233/ajchem.2024.31565
Om Prakash Joshi
Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer-305817, India
https://orcid.org/0000-0002-6135-8730
Ankit Kumar Dash
Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer-305817, India
Ramalingam Thirumoorthi
Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer-305817, India
https://orcid.org/0000-0002-5875-0280
Chandrakanta Dash
Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer-305817, India
https://orcid.org/0000-0002-6945-1366

Corresponding Author(s) : Chandrakanta Dash

ckdash@curaj.ac.in

Asian Journal of Chemistry, Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Abstract

An inexpensive iron-catalyzed annulation of 2-aminobenzaldehydes with iodonium ylides for the synthesis of acridinone derivatives was reported. A library of biologically relevant 3,4-dihydropyridine-1-one scaffold was synthesized by the reaction of corresponding 2-amino benzaldehyde and iodonium ylides under mild reaction conditions in a green solvent. The reaction tolerates various alkyl, aryl and halogenated substrates and affords the desired product in moderate to good yields. The reported reaction has an inexpensive catalytic system, mild reaction conditions, easily accessible substrates and the use of green solvents.

Keywords

Heterocycles Acridin-1-one Iron Catalysis Green synthesis
Joshi, O. P., Dash, A. K., Thirumoorthi, R., & Dash, C. (2024). Iron-Catalyzed Annulation of 2-Aminobenzaldehydes with Iodonium Ylides: A Mild and General Route for the Synthesis of Acridinone Derivatives. Asian Journal of Chemistry, 36(6), 1423–1428. https://doi.org/10.14233/ajchem.2024.31565
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