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Vol. 36 No. 9 (2024): Vol 36 Issue 9, 2024

Copyright (c) 2024 Gyanendra Kumar Sharma Gyanendra Kumar Sharma, Gurvinder Pal Singh Gurvinder, Harsh Bhardwaj, Manish Pal Singh, Himanshu Bhardwaj, Akhileshar Prasad Mishra

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Conventional and Microwave Assisted Synthesis of Some Novel 2-(Substituted phenyl)-4,5-diphenyl-1-(thiazol-2-yl)-1H-imidazoles of Biological Interest

https://doi.org/10.14233/ajchem.2024.32044
Gyanendra Kumar Sharma
Sharda School of Pharmacy, Sharda University, Agra-282007, India
https://orcid.org/0000-0003-0973-0483
Gurvinder Pal Singh
Sharda School of Pharmacy, Sharda University, Agra-282007, India
https://orcid.org/0009-0009-1818-0381
Harsh Bhardwaj
Sharda School of Pharmacy, Sharda University, Agra-282007, India
https://orcid.org/0000-0002-2850-3326
Manish Pal Singh
Sharda School of Pharmacy, Sharda University, Agra-282007, India
https://orcid.org/0000-0001-6243-6385
Himanshu Bhardwaj
Institute of Pharmaceutical Sciences, J.S. University, Shikohabad-283135, India
https://orcid.org/0009-0004-3269-4542
Akhileshar Prasad Mishra
Institute of Pharmaceutical Sciences, J.S. University, Shikohabad-283135, India
https://orcid.org/0009-0001-0727-8019

Corresponding Author(s) : Gyanendra Kumar Sharma

gyane007@yahoo.com

Asian Journal of Chemistry, Vol. 36 No. 9 (2024): Vol 36 Issue 9, 2024

Abstract

In present investigation, a straightforward approach to design and synthesize 2-(substituted phenyl)-4,5-diphenyl-1-(thiazol-2-yl)-1H-imidazoles (5a-j) using two methods viz. traditional heating and microwave irradiation and characterized with elemental, FT-IR, 1H NMR, 13C NMR, mass spectrophotometric techniques. The microwave irradiation method offers excellent yields, lesser reaction time and eco-environmental friendly reactions as compared to conventional method. The synthesized compounds were evaluated for their antimicrobial, anticancer and free radical scavenging activity. The findings on the compounds’ in vitro antibacterial activity against Gram-positive and Gram-negative pathogens showed that compounds 5b, 5c and 5g showed potential antibacterial and fungicide efficacy. Using Dalton’s Lymphoma Ascites (DLA) cell lines, the synthesized compounds were further examined for its in vitro anticancer efficacy. Among the synthesized compounds, 5b, 5f, 5g and 5j exhibited excellent anticancer activity with CTC50 value of 31.25 µg/mL, 51.61 µg/mL, 44.21 µg/mL and 31.25 µg/mL, respectively. The synthesized compounds have also shown a marked free radical scavenging capacity in all the concentrations but specifically compounds 5a, 5d, 5e, 5f, 5i and 5j have shown good antioxidant potential with an IC50 value of 25.18 µmol/L, 44.22 µmol/L 35.61 µmol/L, 28.09 µmol/L, 44.47 µmol/L and 39.46 µmol/L, respectively.

Keywords

Imidazo-thiazole Microwave assisted synthesis Antibacterial Anticancer Free radical scavenging
Sharma, G. K., Singh, G. P., Bhardwaj, H., Singh, M. P., Bhardwaj, H., & Mishra, A. P. (2024). Conventional and Microwave Assisted Synthesis of Some Novel 2-(Substituted phenyl)-4,5-diphenyl-1-(thiazol-2-yl)-1H-imidazoles of Biological Interest. Asian Journal of Chemistry, 36(9), 2019–2024. https://doi.org/10.14233/ajchem.2024.32044
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