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Vol. 31 No. 9 (2019): Vol 31 Issue 9

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Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam

https://doi.org/10.14233/ajchem.2019.22156
Xuan Bui Thi
School of Medicine and Pharmacy, Viet nam National University, No.144 Xuan Thuy street, Cau Giay, Hanoi, Vietnam
Loi Vu Duc
School of Medicine and Pharmacy, Viet nam National University, No.144 Xuan Thuy street, Cau Giay, Hanoi, Vietnam
Tung Bui Thanh
School of Medicine and Pharmacy, Viet nam National University, No.144 Xuan Thuy street, Cau Giay, Hanoi, Vietnam
Ngoc Tran Minh
National Institute of Medicinal Materials, Hanoi, Vietnam

Corresponding Author(s) : Xuan Bui Thi

sealotus82@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 9 (2019): Vol 31 Issue 9

Abstract

Five compounds (1-5) were isolated from the leaves of Sanchezia nobilis collected in Nam Dinh province by chromatographic methods. These compounds were identified as: mangiferin (1), β-sitosterol (2), margaric acid (3), ursolic acid (4), oleanolic acid (5). Their structures were elucidated by spectroscopic methods, including mass spectrometry and nuclear magnetic resonance. These compounds were isolated from the leaves of Sanchezia nobilis for the first time. Screening of gastric and duodenal antiulcer effects on indomethacin induced gastric ulcer models showed that n-hexane fraction produced the highest antiulcer activity. Percentage inhibition of gastric ulceration of misoprostol was 22.86 %, while that of n-hexane fraction was 28.57 % (p < 0.05). Evaluation of gastric and duodenal antiulcer effects on acysteamine induced gastric ulcer models showed that this fraction was effective against gastric and duodenal ulcer (83.3 %), improved ulcer damage (54.17 %), significantly reduced the number of mean ulcer and ulcer index (2.00 ± 1.28) but it did not change the area of the ulcer.

Keywords

Sanchezia nobilis Mangiferin β-Sitosterol Margaric acid Ursolic acid Oleanolic acid
Thi, X. B., Duc, L. V., Thanh, T. B., & Minh, N. T. (2019). Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam. Asian Journal of Chemistry, 31(9), 2125–2132. https://doi.org/10.14233/ajchem.2019.22156
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