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Vol. 31 No. 9 (2019): Vol 31 Issue 9

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in silico Single Nucleotide Polymorphism Prediction and Design for Targeting Amyloid Precursor Protein in Alzheimers Disease

https://doi.org/10.14233/ajchem.2019.22020
M. Meghna
Department of Pharmaceutical Chemistry & Analysis, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, AIMS Ponekkara P.O. Kochi-682041, India
B. Athira
Department of Pharmaceutical Chemistry & Analysis, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, AIMS Ponekkara P.O. Kochi-682041, India
T.S. Saranya
Department of Pharmaceutical Chemistry & Analysis, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, AIMS Ponekkara P.O. Kochi-682041, India
Asha Asokan Manakadan
Department of Pharmaceutical Chemistry, Nirmala College of Health Science, Nutmeg Gardens, Kunnappilly P.O. Chalakudy, Thrissur-680311, India
https://orcid.org/0000-0002-3412-7662

Corresponding Author(s) : T.S. Saranya

saranyats19347@aims.amrita.edu

Asian Journal of Chemistry, Vol. 31 No. 9 (2019): Vol 31 Issue 9

Abstract

Alzheimer’s disease is a progressive neurodegenerative disorder, is the common cause of dementia and affect life quality. Present research analysis is based on the amyloid precursor protein as it is one of the major biomarkers of Alzheimer’s disease, the insoluble part of which gets deposited due to the inappropriate cleavage by secretase enzyme. The instrumental part of this study was performed by using Computer Aided Drug Design (CADD). About 23 phytoconstituents were taken, from these constituents rosamarinic acid produced the highest docking score. Preliminary characterizations of all the ligands were conducted using Biovia Discovery studio along with protein characterization, Lipinski rule analysis and ADMET. The in silico analysis convincingly predicted the action of rosamarinic acid, against the formation of amyloid plaque by binding with the amyloid precursor protein .Details of single nucleotide polymorphism on gene APPI were analyzed by dbSNP database and displays the need for further in vitro study.

Keywords

Alzheimer Amyloid protein Biovia docking Secretase Enzyme ProtParam
Meghna, M., Athira, B., Saranya, T., & Manakadan, A. A. (2019). in silico Single Nucleotide Polymorphism Prediction and Design for Targeting Amyloid Precursor Protein in Alzheimers Disease. Asian Journal of Chemistry, 31(9), 1959–1965. https://doi.org/10.14233/ajchem.2019.22020
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