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Vol. 31 No. 7 (2019): Vol 31 Issue 7

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A New Series of Moisture Stable Metallacyclic Heteroleptic Titanium(IV) Complexes of 8-Hydroxyquinoline: Synthesis, Characterization, Stability Study and Cytotoxicity Evaluation

https://doi.org/10.14233/ajchem.2019.22120
Blassan Samuel
Faculty of Education, St. Theresa International College, Bangkok-26120, Thailand
Madhvesh Pathak
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

Corresponding Author(s) : Blassan Samuel

blassansamuel@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 7 (2019): Vol 31 Issue 7

Abstract

A new series of moisture resistant metallacyclic titanium(IV) derivatives prepared from 8-hydroxyquinoline of the general formulae [(Q2)Ti{(L1)(L2OR)}] (3a-b, 3d-e), [(Q2)Ti{(L1)(L3)}] (3c and 3f) and [(Q2)Ti(L4)] (3g and 3h) is synthesized by interacting the precursor molecule [(Q2)Ti(OiPr)2] (2) with various 2-heteroaryl methyl ketone oximes and various alkoxyalkanols/2-hydroxypyridine or only with catechol/resorcinol in 1:1:1 or in 1:1 molar ratios in anhydrous boiling toluene (where, HQ = 8-hydroxyquinoline; iPr = isopropyl; L1H = HONC(Me)py-2/HONC(Me)fu-2; L2 = O-CH2-CH2-; R = CH3, C2H5; L3H = 2-hydroxypyridine and L4H = catechol/resorcinol). Stability study revealed that these molecules were stable for a period of 72 h. Mononuclear nature of the complexes was confirmed through mass spectral analysis. Thermogravimetric results explain the multistage fragmentation of the complexes at 900 ºC. NMR, FTIR, and UV-visible spectral data suggested that titanium-ligands attachment is in a hexa-coordinated manner. Additionally, all these molecules were tested for their tumour inhibiting potential against MDA-MB-231 human breast carcinoma cell line.

Keywords

8-Hydroxyquinoline Titanium complexes Cytotoxicity evaluation Moisture stability Metal-to-ligand charge transfer
Samuel, B., & Pathak, M. (2019). A New Series of Moisture Stable Metallacyclic Heteroleptic Titanium(IV) Complexes of 8-Hydroxyquinoline: Synthesis, Characterization, Stability Study and Cytotoxicity Evaluation. Asian Journal of Chemistry, 31(7), 1629–1635. https://doi.org/10.14233/ajchem.2019.22120
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