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Vol. 31 No. 7 (2019): Vol 31 Issue 7

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A Novel Method for Synthesis and their Antimicrobial Activity of 1H-Tetrazole Based Flavones and Flavanone Derivatives under Ultrasonic and Microwave Irradiation Methods

https://doi.org/10.14233/ajchem.2019.21925
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
N. Nagaraju
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
Ravinder Dharavath
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
M. Ram Reddy
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
K. Ramakrishna
Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500007, India
M. Sarasija
Department of Chemistry, Satavahana University, Karimnagar-505001, India

Corresponding Author(s) : D. Ashok

ashokdou@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 7 (2019): Vol 31 Issue 7

Abstract

A series of novel tetrazole scaffolds containing flavones and flavanones have been synthesized under conventional, ultrasonic and microwave irradiation methods. All the newly synthesized compounds were characterized by IR, NMR and Mass spectral analysis. Furthermore, the title compounds were screened in vitro antimicrobial activity against bacteria such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli as well as fungi such as Aspergillus niger, Aspergillus flavus and Fusarium oxysporum. Some of the compounds showed good activity compared to standard drugs against all pathogenic bacteria and fungi.

Keywords

Flavones Flavanones Ultrasonication Microwave irradiation Antimicrobial activity
Ashok, D., Nagaraju, N., Dharavath, R., Reddy, M. R., Ramakrishna, K., & Sarasija, M. (2019). A Novel Method for Synthesis and their Antimicrobial Activity of 1H-Tetrazole Based Flavones and Flavanone Derivatives under Ultrasonic and Microwave Irradiation Methods. Asian Journal of Chemistry, 31(7), 1495–1500. https://doi.org/10.14233/ajchem.2019.21925
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