Copyright (c) 2019 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Eco-Friendly Synthesis of Solid-Support Bis-Dihydropyrimidines and their Antimicrobial Studies
Corresponding Author(s) : Balbir Kaur
Asian Journal of Chemistry,
Vol. 31 No. 7 (2019): Vol 31 Issue 7
Abstract
This article is aimed at the synthesis of new bis-dihydropyrimidines using solid-support. The reactions were carried out using microwave energy. Presented protocol is associated with higher yields of desired products, easier work-up conditions, less reaction times, higher reproducibility and maximum efficiency of method in comparison to conventional heating. The structures of prepared moieties were confirmed by spectroscopic techniques. Further, these bis-heterocycles were also examined for their biological behaviours. Agar well diffusion method was used to carry out in-vitro antimicrobial evaluations. Compound 6j came forward as most active antibacterial and 6b proved itself to be the most potent antifungal agent.
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- P. Vicini, A. Geronikaki, K. Anastasia, M. Incerti and F. Zani, Bioorg. Med. Chem., 14, 3859 (2006); https://doi.org/10.1016/j.bmc.2006.01.043.
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References
P. Vicini, A. Geronikaki, K. Anastasia, M. Incerti and F. Zani, Bioorg. Med. Chem., 14, 3859 (2006); https://doi.org/10.1016/j.bmc.2006.01.043.
O. Bozdag-Dündar, Ö. Özgen, A. Mentese, N. Altanlar, O. Atli, E. Kendi and R. Ertan, Bioorg. Med. Chem., 15, 6012 (2007); https://doi.org/10.1016/j.bmc.2007.06.049.
A. Cukurovali, I. Yilmaz, S. Gur and C. Kazaz, Eur. J. Med. Chem., 41, 201 (2006); https://doi.org/10.1016/j.ejmech.2005.01.013
M.M. Ramla, M.A. Omar, A.-M.M. El-Khamry and H.I. El-Diwani, Bioorg. Med. Chem., 14, 7324 (2006); https://doi.org/10.1016/j.bmc.2006.06.033.
E. Gürsoy and N.U. Güzeldemirci, Eur. J. Med. Chem., 42, 320 (2007); https://doi.org/10.1016/j.ejmech.2006.10.012.
M.-H. Shih and F.-Y. Ke, Bioorg. Med. Chem., 12, 4633 (2004); https://doi.org/10.1016/j.bmc.2004.06.033.
M.R. Shiradkar, K.K. Murahari, H.R. Gangadasu, T. Suresh, C.A. Kalyan, D. Panchal, R. Kaur, P. Burange, J. Ghogare, V. Mokale and M. Raut, Bioorg. Med. Chem., 15, 3997 (2007); https://doi.org/10.1016/j.bmc.2007.04.003.
G. Aridoss, S. Amirthaganesan, M.S. Kim, J.T. Kim and Y.T. Jeong, Eur. J. Med. Chem., 44, 4199 (2009); https://doi.org/10.1016/j.ejmech.2009.05.015.
L. Louis, EU Patent 263,020 (1998); Chem. Abstr., 109, 128995q (1998).
B.S. Holla, K.V. Malini, B.S. Rao, B.K. Sarojini and N.S. Kumari, Eur. J. Med. Chem., 38, 313 (2003); https://doi.org/10.1016/S0223-5234(02)01447-2.
R.G. Kalkhambkar, G.M. Kulkarni, H. Shivkumar and N.R. Rao, Eur. J. Med. Chem., 42, 1272 (2007); https://doi.org/10.1016/j.ejmech.2007.01.023.
D.R. Hannah and M.F.G. Stevens, J. Chem. Res., 398 (2003); https://doi.org/10.3184/030823403103174533.
S. Kaur, R. Kaur, B. Kaur and M. Yusuf, Int. J. Curr. Res., 5, 1589 (2013).
M. Bansal, R. Kaur and B. Kaur, Heterocycl. Commun., 15, 417 (2009); https://doi.org/10.1515/HC.2009.15.6.417.
P. Biginelli, Gazz. Chim. Ital., 23, 360 (1893).
J. Threlfall, I.S.T. Fisher, L.R. Ward, H. Tschäpe and P. Gerner-Smidt, Microb. Drug Resist., 5, 195 (1999); https://doi.org/10.1089/mdr.1999.5.195.
S.K. Bhatia, V. Samdhian and B. Kaur, J. Het. Chem., 55, 935 (2018); https://doi.org/10.1002/jhet.3121.