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Vol. 31 No. 7 (2019): Vol 31 Issue 7

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Synthesis of Substituted 4-(4-((3-Nitro-2-oxo-2H-chromene-4-yl)amino)phenyl)morpholine-3-one Coumarin Derivatives

https://doi.org/10.14233/ajchem.2019.21860
Yogesh J. Sanghani
Department of Chemistry, School of Science, R K University, Rajkot-360020, India
https://orcid.org/0000-0002-0739-5039
Suresh B. Koradiya
Department of Chemistry, Shree M. & N. Virani Science College, Rajkot-360005, India
Anilkumar S. Patel
Department of Chemistry, Shree M. & N. Virani Science College, Rajkot-360005, India

Corresponding Author(s) : Yogesh J. Sanghani

yogeshsanghani481@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 7 (2019): Vol 31 Issue 7

Abstract

A series of novel 4-(4-amino phenyl) morpholine-3-one substituted coumarin derivatives have been prepared by chloramine coupling reaction and were identified. The novel synthetic route involves nucleophilic substitution reaction of 4-chloro-3-nitro-2H-chromene-2-one with 4-(4-amino phenyl)morpholine-3-one. Due to the presence of nitro group in coumarin derivatives make substitution reaction easy and convenient at low temperature. Using DMF as solvent and K2CO3 as base various substituted 4-(4-((3-nitro-2-oxo-2H-chromen-4-yl)amino)phenyl)morpholine-3-one derivatives (YS-1 to YS-10) can be obtain in good yield and high purity. Structural characterization of all synthesized compound was done by NMR, Mass and IR spectra.

Keywords

4-Chloro-3-nitro-2H-chromene-2-one 4-(4-Amino phenyl)morpholine-3-one 4-Hydroxy coumarin
Sanghani, Y. J., Koradiya, S. B., & Patel, A. S. (2019). Synthesis of Substituted 4-(4-((3-Nitro-2-oxo-2H-chromene-4-yl)amino)phenyl)morpholine-3-one Coumarin Derivatives. Asian Journal of Chemistry, 31(7), 1461–1464. https://doi.org/10.14233/ajchem.2019.21860
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