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Vol. 31 No. 6 (2019): Vol 31 Issue 6

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A Facile Solvent-Free Route for One-Pot Multicomponent Synthesis of Benzylpyrazolyl Coumarins Derivatives in Presence of Effective Synergetic Catalytic System

https://doi.org/10.14233/ajchem.2019.21986
Narendra R. Kamble
Department of Chemistry, PDEA’s Waghire College, Saswad-412301, India
Vinod T. Kamble
Organic Chemistry Research Laboratory, Department of Chemistry, Institute of Sciences, Nagpur-440008, India

Corresponding Author(s) : Narendra R. Kamble

narendra1499@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 6 (2019): Vol 31 Issue 6

Abstract

A combinatorial library of benzylpyrazolyl coumarin derivatives have been synthesized by a green one-pot four-component reaction between aryl hydrazine/hydrazine hydrate (1), ethyl acetoacetate (2), aromatic aldehydes (3) and 4-hydroxycoumarin (4) catalyzed by niobium pentachloride with silver salt under solvent-free conditions has been developed. Experimental simplicity, simple work-up procedure and solvent-free reaction condition at room temperature are important features of the present protocol.

Keywords

Niobium pentachloride Silver salt Benzylpyrazolyl coumarin
Kamble, N. R., & Kamble, V. T. (2019). A Facile Solvent-Free Route for One-Pot Multicomponent Synthesis of Benzylpyrazolyl Coumarins Derivatives in Presence of Effective Synergetic Catalytic System. Asian Journal of Chemistry, 31(6), 1357–1361. https://doi.org/10.14233/ajchem.2019.21986
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