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Vol. 31 No. 6 (2019): Vol 31 Issue 6

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Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline

https://doi.org/10.14233/ajchem.2019.21889
P.R. Chetana
Department of Chemistry, Central College Campus, Bangalore University, Bengaluru-560001, India
D.R. Navya
Department of Chemistry, Central College Campus, Bangalore University, Bengaluru-560001, India
Vibha Vinayakumar Bhat
Department of Chemistry, Central College Campus, Bangalore University, Bengaluru-560001, India
B.S. Srinatha
Department of Chemistry, Forensic Science Laboratory, Bengaluru-560068, India
Mohan A. Dhale
Department of Microbiology and Fermentation Technology, Central Food Technological Research Institute, Mysore-570020, India

Corresponding Author(s) : P.R. Chetana

pr.chetana@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 6 (2019): Vol 31 Issue 6

Abstract

A series of lanthanum(III) complexes [La(4-qtpy)2(NO3)2](NO3) (1), [La(4-qtpy)3(NO3)](NO3)2 (2), [La(4-qtpy)(phen)(NO3)2](NO3) (3) and [La(4-qtpy)(phen)2(NO2)2](NO3) (4) (4-qtpy = 4′-[(4-quinoline)- 2,2′;6′,2′′-terpyridine]) were synthesized and characterized. The cyclic voltammetric studies revealed that the complexes 1 and 3 are redox active. UV-visible absorption spectral studies and viscosity measurements revealed that complexes bind to DNA through intercalation. Complexes 1 and 3 have shown the highest binding propensity (Kb = 4.241 + 0.2 × 106 for 1 and 1.492 + 0.2 × 106 for 3). The results of chemical nuclease studies revealed that the complexes 3 and 4 have shown maximum chemical nuclease activity in the presence of H2O2 and the mechanism involves hydroxyl radicals. The antibacterial activities of the complexes 1 to 4 were tested against Gram positive and Gram negative bacteria in which complex 3 shows comparable results with the standard antibiotic tetracycline. The cytotoxic activities of 4-qtpy and complex 4 were done by MTT assay against HeLa cell lines.

Keywords

Terpyridine complexes Lanthanum(III) complexes Antibacterial activity Cytotoxic study
Chetana, P., Navya, D., Bhat, V. V., Srinatha, B., & Dhale, M. A. (2019). Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline. Asian Journal of Chemistry, 31(6), 1265–1274. https://doi.org/10.14233/ajchem.2019.21889
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