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Vol. 31 No. 5 (2019): Vol 31 Issue 5

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Water-Mediated Ceric Ammonium Nitrate Catalyzed C-C/C-N Bond Formation: Convenient Access to Polyfunctionalized Pyrazoles via Multicomponent Reaction

https://doi.org/10.14233/ajchem.2019.21947
Vikas D. Kadu
Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur-413255, India
https://orcid.org/0000-0001-7286-093X
Mahesh G. Hublikar
Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur-413255, India
https://orcid.org/0000-0003-1442-9206
Dattatraya G. Raut
Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur-413255, India
https://orcid.org/0000-0003-2684-3383
Raghunath B. Bhosale
Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur-413255, India
https://orcid.org/0000-0002-1680-9600

Corresponding Author(s) : Raghunath B. Bhosale

bhosale62@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 5 (2019): Vol 31 Issue 5

Abstract

An efficient multicomponent approach has been developed in the environmentally green aqueous medium for synthesis of substituted polyfunctionalized pyrazoles. The simple and readily available aldehydes, malononitrile and phenylhydrazines substrates afforded polysubstituted imidazoles (15 examples) up to 96 % yield. The polyethylene glycol is playing the dual role of solvent and promoter with water in this reaction catalyzed by ceric ammonium nitrate.

Keywords

Multicomponent reaction Pyrazole Water-polyethylene glycol media Ceric ammonium nitrate
Kadu, V. D., Hublikar, M. G., Raut, D. G., & Bhosale, R. B. (2019). Water-Mediated Ceric Ammonium Nitrate Catalyzed C-C/C-N Bond Formation: Convenient Access to Polyfunctionalized Pyrazoles via Multicomponent Reaction. Asian Journal of Chemistry, 31(5), 1189–1194. https://doi.org/10.14233/ajchem.2019.21947
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