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Vol. 31 No. 5 (2019): Vol 31 Issue 5

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Interaction of Lorazepam with Planar Bilayer Lipid Membrane and Development of Impedimetric Sensor

https://doi.org/10.14233/ajchem.2019.21920
S. Sivakumar
Department of Chemistry, Kandaswami Kandar’s College, P. Velur, Namakkal-638182, India; Advanced Biomaterial Laboratory, Department of Chemistry, Sri Vijay Vidyalaya College of Arts and Science, Dharmapuri-636807, India
S. Rameshkumar
Department of Chemistry, Sri Vasavi College, Erode-638316, India
S. Sathishkumar
Advanced Biomaterial Laboratory, Department of Chemistry, Sri Vijay Vidyalaya College of Arts and Science, Dharmapuri-636807, India
A. Sankar
Department of Chemistry, Kandaswami Kandar’s College, P. Velur, Namakkal-638182, India

Corresponding Author(s) : A. Sankar

sivasankarchem2018@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 5 (2019): Vol 31 Issue 5

Abstract

Artificial planar bilayer phospholipid membrane was formed in KCl bath solutions and its electrical properties have been analyzed using electrochemical impedance spectroscopy. The stability of planar bilayer lipid membrane depends on concentration of KCl in the bath. Changes in the electrical properties of planar bilayer lipid membrane with the addition of lorazepam were also studied using electrochemical impedance spectroscopy. Lorazepam gets partitioned into bilayer lipid membrane and exhibited a fluidization effect. The ionic conductance across the bilayer lipid membrane increased with the addition of lorazepam to the bath. An impedimetric sensor was developed for quantification of lorazepam in solution.

Keywords

Planar bilayer lipid membrane Lorazepam EIS Drug–membrane interaction Capacitance
Sivakumar, S., Rameshkumar, S., Sathishkumar, S., & Sankar, A. (2019). Interaction of Lorazepam with Planar Bilayer Lipid Membrane and Development of Impedimetric Sensor. Asian Journal of Chemistry, 31(5), 1169–1175. https://doi.org/10.14233/ajchem.2019.21920
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