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Vol. 31 No. 5 (2019): Vol 31 Issue 5

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Synthesis and Antimicrobial Activity of Piperine Analogues Containing 1,2,4-Triazole Ring

https://doi.org/10.14233/ajchem.2019.21876
Kottakki Naveen Kumar
Department of Chemistry, GITAM University, Visakhapatnam-530045, India
Karteek Rao Amperayani
Department of Chemistry, GITAM University, Visakhapatnam-530045, India
V. Ravi Sankar Ummdi
Molecular Biology Division, MicGene Lab, Visakhapatnam-530017, India
Uma Devi Parimi
Department of Chemistry, Gayatri Vidya Parishad College for Degree and P.G. Courses (A), Visakhapatnam-530045, India

Corresponding Author(s) : Uma Devi Parimi

umadevichemistry@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 5 (2019): Vol 31 Issue 5

Abstract

A series 1,2,4-triazole piperine analogues (TP1-TP6) were designed and synthesized. The structures were confirmed using 1H NMR and 13C NMR. Antibacterial study was done using Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative micro-organisms (E. coli and Pseudomonas aeruginosa) by disc diffusion method. Compound containing chloro substitution (TP6) showed the highest effect, while compound TP1, TP3, TP4, TP5 showed the moderate activity.

Keywords

Piperine-triazole analogues Antimicrobial activity
Kumar, K. N., Amperayani, K. R., Sankar Ummdi, V. R., & Parimi, U. D. (2019). Synthesis and Antimicrobial Activity of Piperine Analogues Containing 1,2,4-Triazole Ring. Asian Journal of Chemistry, 31(5), 1077–1080. https://doi.org/10.14233/ajchem.2019.21876
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