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Vol. 31 No. 4 (2019): Vol 31 Issue 4

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Synthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1'-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes

https://doi.org/10.14233/ajchem.2019.21732
Manoj Kumar
Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134007, India
Pallvi
Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134007, India
Hardeep Singh Tuli
Department of Biotechnology, Maharishi Markandeshwar University (Deemed to be University), Mullana-Ambala-133207, India
Rajshree Khare
Department of Chemistry, Maharishi Markandeshwar University (Deemed to be University), Mullana-Ambala-133207, India

Corresponding Author(s) : Manoj Kumar

manojraju27@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 4 (2019): Vol 31 Issue 4

Abstract

Novel Schiff base and its two transition metal complexes derived from the condensation reaction of 2,6-diacetylpyridine with biguanide, characterized by 1H NMR, IR and elemental analysis. The ligand and its cobalt(II) and nickel(II) complexes showed potent DNA photo-cleavage activity. Antimicrobial activity of this Schiff base and its cobalt(II) and nickel(II) complexes against bacteria and fungi viz. S. aureus, K. pneumoniaae and A. niger, Trichophyton rubrum, respectively was evaluated in terms of zone of inhibition.

Keywords

Cobalt(II) Nickel(II) Complexes 2,6-Diacetylpyridine Biguanide DNA Photo-cleavage
Kumar, M., Pallvi, ., Tuli, H. S., & Khare, R. (2019). Synthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1’-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes. Asian Journal of Chemistry, 31(4), 799–804. https://doi.org/10.14233/ajchem.2019.21732
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