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Vol. 31 No. 4 (2019): Vol 31 Issue 4

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Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

https://doi.org/10.14233/ajchem.2019.21623
Venkata Swamy Tangeti
Department of Chemistry, Dr. Sarvepalli Radha Krishnan Government Arts College (Pondicherry University), Yanam-533464, India
K.V.V.V. Satyanarayana
Department of Chemistry, Dr. Sarvepalli Radha Krishnan Government Arts College (Pondicherry University), Yanam-533464, India

Corresponding Author(s) : Venkata Swamy Tangeti

swamychempcu@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 4 (2019): Vol 31 Issue 4

Abstract

A series of sulfonyl dihydrofuropyrazole derivatives was prepared from one pot multi component condensation of sulfonated β-keto ester, aromatic aldehyde, hydrazine, pyridinium ylide in presence of piperidine catalyst under ethanol solvent conditions and subsequent oxidation of SPh group with MCPBA. All the synthesized compounds were characterized by analytical and spectral techniques and screened in vitro for antimicrobial activity. The activity data revealed that most of the compounds exhibited good to significant activities. Compounds 6b, 6i, 6j, 6k, 6m, 6n exhibited good and broad spectrum activity towards all the tested bacterial strains.

Keywords

Sulfonated dihydrofuropyrazole Phenylthio β-keto ester Blaise reaction Antimicrobial activity
Tangeti, V. S., & Satyanarayana, K. (2019). Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents. Asian Journal of Chemistry, 31(4), 773–779. https://doi.org/10.14233/ajchem.2019.21623
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