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Vol. 31 No. 3 (2019): Vol 31 Issue 3

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Synthesis of Some Hippuric Acid Substrate Linked Novel Pyrazoles as Antimicrobial Agents

https://doi.org/10.14233/ajchem.2019.21671
Anil Verma
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133201, India
Vinod Kumar
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133201, India
Rajshree Khare
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133201, India
Joginder Singh
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133201, India

Corresponding Author(s) : Joginder Singh

joginderchem@mmumullana.org

Asian Journal of Chemistry, Vol. 31 No. 3 (2019): Vol 31 Issue 3

Abstract

Escalating resistance of microorganisms to the currently accessible antimicrobial drugs has forced to synthesize some novel biologically active compounds as efficient alternates via economical substrates. Hence, hippuric acid was used as one of the starting materials to synthesize pyrazole derivatives. All the synthesized compounds were characterized by IR, NMR (1H & 13C) and mass spectral data. The antimicrobial potential of synthesized compounds has been explored against four bacterial and two fungal strains. Among the 12 compounds, 3 compounds 8j, 8k and 8l were found to exhibit prominent antimicrobial potential as compared with the standards ciprofloxacin and amphotericin-B.

Keywords

Hippuric acid Pyrazoles Antimicrobial agent Ciprofloxacin Amphotericin-B
Verma, A., Kumar, V., Khare, R., & Singh, J. (2019). Synthesis of Some Hippuric Acid Substrate Linked Novel Pyrazoles as Antimicrobial Agents. Asian Journal of Chemistry, 31(3), 522–526. https://doi.org/10.14233/ajchem.2019.21671
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References
  1. V. Kumar, K. Kaur, G.K. Gupta and A.K. Sharma, Eur. J. Med. Chem., 69, 735 (2013a); https://doi.org/10.1016/j.ejmech.2013.08.053.
  2. K. Kaur, V. Kumar, A.K. Sharma and G.K. Gupta, Eur. J. Med. Chem., 77, 121 (2014); https://doi.org/10.1016/j.ejmech.2014.02.063.
  3. G.S. Hassan, S.M. El-Messery, F.A.M. Al-Omary and H.I. El-Subbagh, Bioorg. Med. Chem. Lett., 22, 6318 (2012); https://doi.org/10.1016/j.bmcl.2012.08.095.
  4. V. Kumar, R. Aggarwal, P. Tyagi and S.P. Singh, Eur. J. Med. Chem., 40, 922 (2005); https://doi.org/10.1016/j.ejmech.2005.03.021.
  5. R. Aggarwal, V. Kumar, P. Tyagi and S.P. Singh, Bioorg. Med. Chem., 14, 1785 (2006); https://doi.org/10.1016/j.bmc.2005.10.026.
  6. R.M. Mohareb, N.N.E. El-Sayed and M.A. Abdelaziz, Molecules, 17, 8449 (2012); https://doi.org/10.3390/molecules17078449.
  7. J.P. Raval, A.B. Shah, N.H. Patel, H.V. Patel, P.S. Patel, K.K. Bhatt and K.R. Desai, Eur. J. Med. Chem., 2, 238 (2011); https://doi.org/10.5155/eurjchem.2.2.238-242.206.
  8. G.K. Gupta, V. Kumar and V. Kumar, Res. J. Chem. Environ., 15, 90 (2011).
  9. V. Kumar, K. Kaur, G.K. Gupta, A.K. Gupta and S. Kumar, Recent Pat. Inflamm. Allergy Drug Discov., 7, 124 (2013); https://doi.org/10.2174/1872213X11307020004.
  10. M. Abdel-Aziz, G.E.-D.A. Abuo-Rahma and A.A. Hassan, Eur. J. Med. Chem., 44, 3480 (2009); https://doi.org/10.1016/j.ejmech.2009.01.032.
  11. H. Bektas, N. Karaali, D. Sahin, A. Demirbas, S.A. Karaoglu and N. Demirbas, Molecules, 15, 2427 (2010); https://doi.org/10.3390/molecules15042427.
  12. R. Kumar, R.R. Nair, S.S. Dhiman, J. Sharma and O. Prakash, Eur. J. Med. Chem., 44, 2260 (2009); https://doi.org/10.1016/j.ejmech.2008.06.004.
  13. M. Shiradkar, G.V. Suresh Kumar, V. Dasari, S. Tatikonda, K.C. Akula and R. Shah, Eur. J. Med. Chem., 42, 807 (2007); https://doi.org/10.1016/j.ejmech.2006.12.001.
  14. K. Sztanke, T. Tuzimski, J. Rzymowska, K. Pasternak and M. KandeferSzerszeñ, Eur. J. Med. Chem., 43, 404 (2008); https://doi.org/10.1016/j.ejmech.2007.03.033.
  15. L.T. Yu, M.T. Ho, C.Y. Chang and T.K. Yang, Tetrahedron Asymm., 18, 949 (2007); https://doi.org/10.1016/j.tetasy.2007.03.015.
  16. B.D. Mistry, K.R. Desai, J.A. Patel and N.I. Patel, Indian J. Chem., 51B, 746 (2012).
  17. M.D. Amdare, K.R. Jogdand, L. Kathane, N. Ganesh, C.D. Padole, and D.K. Mahapatra D, J. Pharm. Chem. Biol. Sci., 5, 216 (2017).
  18. C.A.B. Rodrigues, J.M.G. Martinho and C.A.M. Afonso, J. Chem. Educ., 92, 1543 (2015); https://doi.org/10.1021/ed500212t.
  19. C. Nagamani, S.M. Basavarajaiah, S. Nagaraj and C.S. Devi, Int. J. Comput. Eng. Res., 6, 2250 (2016).
  20. R. Ahmed, Indian J. Soc. Res., 13, 126 (2017).
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