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Vol. 31 No. 3 (2019): Vol 31 Issue 3

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in vitro Cytotoxic Evaluation of Some New Synthesized Pyridazine Derivatives

https://doi.org/10.14233/ajchem.2019.21832
Sara Nabil
Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
https://orcid.org/0000-0002-1438-2236
Abeer Obaid Al-Dossary
Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
https://orcid.org/0000-0001-6988-9627

Corresponding Author(s) : Sara Nabil

snabil@iau.edu.sa

Asian Journal of Chemistry, Vol. 31 No. 3 (2019): Vol 31 Issue 3

Abstract

A series of novel pyridazine, pyrazoles, pyrimidines derivatives have been synthesized through the reaction of chloropyridazine (1) with p-phenylenediamine to give compound 2. Diazotization of compound 2 followed by coupling with active methylene compounds namely acetylacetone, ethylcyanoacetate and/or ethylacetoacetate afforded novel hydrazons derivatives (4-6). The resulting hydrazons can have been cyclized using hydrazine hydrate and guanidine gave the corresponding pyrazoles (7-9) and pyimidine (10) derivatives. Reaction of compound 2 with acrylonitrile, aromatic aldehyde, p-chloroacetophenone and phenyl isothiocyanate gave compounds 11, 12a, 12b, 13 and 17, respectively. The latter compounds have been used in synthesis of some heterocyclic compounds. The cytotoxic activity of the most active compounds was assessed in vitro against breast carcinoma cell line (MCF-7), human liver cancer cell line (HEPG2), human colon cancer cell line (HCT). Compounds 4, 8 showed best activity against MCF-7 cell line, compounds 5, 13a showed best activity against HePG2 cell line and compound 10 showed best activity against HCT cell line.

Keywords

Pyridazine Pyrazoles Pyrimidines Hydrazones Anticancer Antitumor activity
Nabil, S., & Al-Dossary, A. O. (2019). in vitro Cytotoxic Evaluation of Some New Synthesized Pyridazine Derivatives. Asian Journal of Chemistry, 31(3), 744–750. https://doi.org/10.14233/ajchem.2019.21832
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