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Vol. 31 No. 3 (2019): Vol 31 Issue 3

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Novel and Environmentally Friendly Synthesis of Pimavanserin (5-HT2A Receptor)

https://doi.org/10.14233/ajchem.2019.21808
Rajesh Kumar Rapolu
Granules India Limited, R & D Center, Plot No. 56, Road No. 5, ALEAP Industrial Area, Pragathi Nagar, Hyderabad-500072, India; Department of Sciences and Humanities, Vignan's Foundation for Science, Technology and Research University (VFSTR), Vadlamudi, Guntur-522213, India
V.V.N.K.V. Prasada Raju
Granules India Limited, R & D Center, Plot No. 56, Road No. 5, ALEAP Industrial Area, Pragathi Nagar, Hyderabad-500072, India
Murthy Chavali
Department of Sciences and Humanities, Vignan's Foundation for Science, Technology and Research University (VFSTR), Vadlamudi, Guntur-522213, India
Naveen Mulakayala
SVAK Lifesciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad-500090, India

Corresponding Author(s) : Naveen Mulakayala

naveen071280@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 3 (2019): Vol 31 Issue 3

Abstract

Eco-friendly synthesis of pimavanserin was developed from the key starting material 4-isobutoxy benzylamine in three different routes using water as solvent. These reactions provide an advantage of easy workup, good yields of products and uses water as the solvent. No column purification was required for the isolation of the product.

Keywords

Pimavanserin Parkinson disease Nuplazid Dopamine receptor
Rapolu, R. K., Prasada Raju, V., Chavali, M., & Mulakayala, N. (2019). Novel and Environmentally Friendly Synthesis of Pimavanserin (5-HT2A Receptor). Asian Journal of Chemistry, 31(3), 723–726. https://doi.org/10.14233/ajchem.2019.21808
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