Issue

Vol. 31 No. 3 (2019): Vol 31 Issue 3

Copyright (c) 2019 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

https://doi.org/10.14233/ajchem.2019.21789
Hathama Razooki Hasan
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
Nuha Nihad A. Aburahma
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
Abdul Kareem A. AL-Kazaz
Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq

Corresponding Author(s) : Hathama Razooki Hasan

hathamahasan@scbaghdad.com; hathama2012@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 3 (2019): Vol 31 Issue 3

Abstract

The present study aimed to look for the differences in the oxidative stress status in sera and saliva samples of type 2 diabetic Iraqi patients with and without proliferative diabetic retinopathy. As well as to look for the possibility whether this status can be measured in saliva as an alternative sample to that of serum, hence to achieve that total oxidant status, total antioxidant status and oxidative stress index were measured in both sera and saliva samples of two groups of patients with type 2 diabetes mellitus and the healthy individuals. Upon the comparison between patients without proliferative diabetic retinopathy and the control sample the results showed presence of a significant increase (p < 0.05) of total oxidant status and oxidative stress index in sera and saliva samples, while there was a significant decrease (p < 0.05) in total antioxidant status of sera and saliva samples. Meanwhile when the comparison was done between patients with proliferative diabetic retinopathy and those without proliferative diabetic retinopathy, a significant increase (p < 0.05) in both salivary total oxidant status and oxidative stress index was observed with a significant decrease (p < 0.05) in sera and salivary total antioxidant status were found in the proliferative diabetic retinopathy patients group.

Keywords

Oxidative stress index Proliferative diabetic retinopathy Type 2 diabetes mellitus Iraqi patients
Hasan, H. R., A. Aburahma, N. N., & A. AL-Kazaz, A. K. (2019). Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy. Asian Journal of Chemistry, 31(3), 719–722. https://doi.org/10.14233/ajchem.2019.21789
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. D. Cavan, L. Makaroff, J. Da Rocha Fernandes, M. Sylvanowicz, P. Ackland, J. Conlon, D. Chaney, A. Malhi and J. Barratt, Diabetes Res. Clin. Pract., 129, 16 (2017); https://doi.org/10.1016/j.diabres.2017.03.023.
  2. D.S.W. Ting and T.Y. Wong, Lancet, 389, 2165 (2017); https://doi.org/10.1016/S0140-6736(17)31194-7.
  3. F.A. Ganjifrockwala, J. Joseph and G. George, J. Endocrinol. Metabol. Diab. South Africa, 22, 21 (2017); https://doi.org/10.1080/16089677.2017.1324590.
  4. J.T. Joseph, F. Ganjifrockwala and G. George, Int. J. Diabetes Dev. Ctries., 31, 75 (2018); https://doi.org/10.1007/s13410-017-0559-0.
  5. A.J. Rani and S. Mythili, J. Clin. Diagn. Res., 8, 108 (2014); https://doi.org/10.7860/JCDR/2014/7603.4121.
  6. P. Saha, P. Banerjee, L. Auddya, P. Pal, M. Das, M. Dutta, S. Sen, M.C. Mondal, A. Kumar and U.K. Biswas, Arch. Med., 7, 5 (2015).
  7. H.R. Hasan, N.N.A. Aburahma and A.A. Al-Kazaz, Orient. J. Chem., 33, 2776 (2017); https://doi.org/10.13005/ojc/330610.
  8. O. Erel, Clin. Biochem., 38, 1103 (2005); https://doi.org/10.1016/j.clinbiochem.2005.08.008.
  9. O. Erel, Clin. Biochem., 37, 112 (2004); https://doi.org/10.1016/j.clinbiochem.2003.10.014.
  10. A. Aycicek and O. Erel, J. Pediatr., 83, 319 (2007).
  11. O. Kose, V. Canakci, C.F. Canakci, A. Yildirim, E. Kermen, T. Arabaci and A. Gungor, Oxid. Antioxid. Med. Sci., 3, 153 (2014); https://doi.org/10.5455/oams.040714.or.069.
  12. E. Beyazyildiz, A.B. Çankaya, E. Ergan, M.A. Anayol, Y. Özdamar, S. Sezer, M.H. Tirhis, P. Yilmazbas and F. Öztürk, Int. J. Ophthalmol., 6, 531 (2013); https://doi.org/10.3980/j.issn.2222-3959.2013.04.23.
  13. R. Naruse, M. Suetsugu, T. Terasawa, K. Ito, K. Hara, K. Takebayashi, K. Morita, Y. Aso and T. Inukai, Saudi Med. J., 34, 135 (2013).
  14. I. Cilenšek, S. Mankoè, M.G. Petroviè and D. Petroviè, Dis. Markers, 32, 93 (2012); https://doi.org/10.1155/2012/675628.
  15. C. Li, X. Miao, F. Li, S. Wang, Q. Liu, Y. Wang and J. Sun, Oxid. Med. Cell. Longev., 2017, 9702820 (2017); https://doi.org/10.1155/2017/9702820.
  16. U.N. Singh, S. Kumar and S. Dhakal, Int. J. Contemp. Med. Res., 4, 1204 (2017).
  17. J.S. Oliveira, A.A.N. Silva and V.A. Silva Jr., Braz. J. Biol., 77, 68 (2016); https://doi.org/10.1590/1519-6984.09915.
  18. O. Merhan, K. Bozukluhan, M. Kuru, F. Buyuk, Ö. Özden and A. Kukurt, Kafkas Univ. Vet. Fak. Derg., 23, 933 (2017); https://doi.org/10.9775/kvfd.2017.18004.
  19. C. Arana, A.M. Moreno-Fernández, G. Gómez-Moreno, C. Morales-Portillo, I. Serrano-Olmedo, M.C. De La Cuesta Mayor and T.M. Hernández, Endocrinol. Diabetes Nutr., 64, 258 (2017); https://doi.org/10.1016/j.endinu.2017.03.005.
  20. D.C. Guzman, H.J. Olguín, E.H. García, A.V. Peraza, D.Z. De La Cruz and M.P. Soto, Redox Rep., 22, 10 (2017); https://doi.org/10.1080/13510002.2016.1205303.
  21. Y. Wu, L. Tang and B. Chen, Oxid. Med. Cell. Longev., 2014, 1 (2014); https://doi.org/10.1155/2014/752387.
  22. I.P. Chatziralli, G. Theodossiadis, P. Dimitriadis, M. Charalambidis, A. Agorastos, Z. Migkos, N. Platogiannis, M.M. Moschos, P. Theodossiadis and P. Keryttopoulos, Open Ophthalmol. J., 11, 51 (2017); https://doi.org/10.2174/1874364101711010051.
  23. R. Mancino, D. Di Pierro, C. Varesi, A. Cerulli, A. Feraco, C. Cedrone, M.D. Pinazo-Duran, M. Coletta and C. Nucci, Mol. Vis., 17, 1298 (2011).
  24. V.S. Reddy, S. Sethi, N. Gupta, P. Agrawal and R.C. Siwach, Retina, 36, 1049 (2016); https://doi.org/10.1097/IAE.0000000000001042.
  25. K. Kirboga, A.V. Ozec, M. Kosker, A. Dursun, M.I. Toker, H. Aydin, H. Erdogan, A. Topalkara and M.K. Arici, J. Ophthalmol., 2014, 1 (2014); https://doi.org/10.1155/2014/820853.
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0