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Vol. 31 No. 12 (2019): Vol 31 Issue 12

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Copper Catalyzed Chan-Lam Coupling Reaction of Pyrazoles at Ambient Temperature and their Antimicrobial Evaluation

https://doi.org/10.14233/ajchem.2019.22370
Kalpesh V. Vilapara
Department of Chemistry, Saurashtra University, Rajkot-360005, India
Sagar P. Gami
Department of Chemistry, Bhavan’s Sheth R.A. College of Science, Ahmedabad-380001, India
Shobhna A. Gadara
Sheth P.T. Arts & Science College, Godhra-389001, India
Yogesh T. Naliapara
Department of Chemistry, Saurashtra University, Rajkot-360005, India

Corresponding Author(s) : Kalpesh V. Vilapara

kalpeshvilapara@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

An efficient protocol to synthesize a series of N-aryl pyrazoles via C-N bond Chan-Lam coupling reaction using diverse boronic acid at room temperature using Cu(OAc)2/TEA as a catalytic system without utilization of any ligand or additive and exposed to air to afford moderate to excellent yield. The characterizations of newly synthesized compounds were confirmed by FTIR, MS, 1H NMR, 13C NMR, and elemental analysis. All the synthesized compounds were assayed for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, B. subtilis MTCC-441, S. typhi MTCC-98, and antifungal activity against Aspergillus niger MTCC-282 and Aspergillus clavatus MTCC-1323 at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method.

Keywords

Chan-Lam coupling N-Aryl pyrazoles Boronic acids Microbial assay
Vilapara, K. V., Gami, S. P., Gadara, S. A., & Naliapara, Y. T. (2019). Copper Catalyzed Chan-Lam Coupling Reaction of Pyrazoles at Ambient Temperature and their Antimicrobial Evaluation. Asian Journal of Chemistry, 31(12), 2981–2985. https://doi.org/10.14233/ajchem.2019.22370
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