Issue

Vol. 31 No. 12 (2019): Vol 31 Issue 12

Copyright (c) 2019 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Simultaneous Estimation of Paracetamol, Phenylephrine Hydrochloride and Triprolidine Hydrochloride by Second Order Derivative Spectroscopy

https://doi.org/10.14233/ajchem.2019.22244
Mukem Bhattarai
Department of Pharmaceutical Analysis and Quality Assurance, Himalayan Pharmacy Institue, Majitar-737136, India
Hema Basnett
Department of Pharmacognosy, Himalayan Pharmacy Institute, Majitar-737136, India
Ateeb Das
Department of Pharmaceutical Analysis and Quality Assurance, Himalayan Pharmacy Institue, Majitar-737136, India
Pravat Manna
Department of Pharmaceutical Analysis and Quality Assurance, Himalayan Pharmacy Institue, Majitar-737136, India
Deepak Chaudhary
Department of Quality Assurance, Gyani Inder Singh Institute of Profesional Studies, Dehradhun-248003, India
Debarupa Dutta
Department of Pharmaceutical Analysis and Quality Assurance, Himalayan Pharmacy Institue, Majitar-737136, India
Bhupendra Shrestha
Department of Pharmaceutical Analysis and Quality Assurance, Himalayan Pharmacy Institue, Majitar-737136, India

Corresponding Author(s) : Bhupendra Shrestha

shrestha2k@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

A simple, sensitive and reproducible second order derivative UV spectrophotometric method was developed for simultaneous estimation of mixture of paracetamol, phenylephrine hydrochloride and triprolidine hydrochloride in the tablet dosage form. The method utilizes second order derivative technique, which helps to isolate the individual peaks of the mixture drugs and overcome the problem of merging of mixture peaks with each other. For quantification of paracetamol, phenylephrine hydrochloride and triprolidine hydrochloride wavelength selected were 244, 276 and 297 nm, respectively. The method was linear over the concentration range of 5-40 μg/mL. Intra-day and inter-day precision were within acceptable range (percentage relative standard deviation 2.27 %). The percentage recovery was within the range between 97.22-99.43 %. The method was also found to be robust and rugged. The method stands validated as per ICH guidelines and hence, can be used for the routine quality control analysis of paracetamol, phenylephrine hydrochloride and triprolidine hydrochloride in the tablet dosage form.

Keywords

Paracetamol Phenylephrine Triprolidine Second order derivative
Bhattarai, M. ., Basnett, H., Das, A., Manna, P., Chaudhary, D., Dutta, D., & Shrestha, B. (2019). Simultaneous Estimation of Paracetamol, Phenylephrine Hydrochloride and Triprolidine Hydrochloride by Second Order Derivative Spectroscopy. Asian Journal of Chemistry, 31(12), 2931–2936. https://doi.org/10.14233/ajchem.2019.22244
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Council of Europe, European Pharmacopoeia, Strasbourg, Council of Europe, p. 2814 (2005).
  2. C.V. Sharma and V. Mehta, Contin. Educ. Anaesth. Crit. Care Pain, 14, 155 (2005); https://doi.org/10.1093/bjaceaccp/mkt049.
  3. British Pharmacopoeia, British Pharmacopoeia Commission, MHRA: London, p. 3221 (2009).
  4. https://pubchem.ncbi.nlm.nih.gov/compound/528444.
  5. L. Brunton, B.A. Chabner and B. Knollman, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, McGraw Hill: New York, edn 20, p. 232 (2001).
  6. J.P. Remington and L.V. Allen, Remington: The Science and Practice of Pharmacy, Pharmaceutical Press, edn 22, p. 1809 (2006).
  7. https://pubchem.ncbi.nlm.nih.gov/compound/5284472.
  8. V.T. Pawar, S.A. Pishawikar and H.N. More, Curr. Phar. Res., 1, 25 (2010); https://doi.org/10.33786/JCPR.2010.v01i01.006.
  9. D.J. Speed, S.J. Dickson, E.R. Cairns and N.D. Kim, J. Anal. Toxicol., 25, 198 (2001); https://doi.org/10.1093/jat/25.3.198.
  10. M.S. Bloomfield, Talanta, 58, 1301 (2002); https://doi.org/10.1016/S0039-9140(02)00421-6.
  11. M.K. Srivastava, S. Ahmad, D. Singh and I.C. Shukla, Analyst, 110, 735 (1985); https://doi.org/10.1039/an9851000735.
  12. K.G. Kumar and R. Letha, J. Pharm. Biomed. Anal., 15, 1725 (1997); https://doi.org/10.1016/S0731-7085(96)01976-0.
  13. C. Celma, J.A. Allue, J. Prunonosa, C. Peraire and R. Obach, J. Chromatogr. A, 870, 77 (2000); https://doi.org/10.1016/S0021-9673(99)01252-2.
  14. D. Satínský, I. Neto, P. Solich, H. Sklenárová, M. Conceicao, B.S. Montenegro and A.N. Araújo, J. Sep. Sci., 27, 529 (2004); https://doi.org/10.1002/jssc.200301644.
  15. L. Monser and F. Darghouth, J. Pharm. Biomed. Anal., 27, 851 (2002); https://doi.org/10.1016/S0731-7085(01)00515-5.
  16. R. Sane and M. Gadgil, J. Planar Chromatogr.-Modern TLC, 15, 77 (2002); https://doi.org/10.1556/JPC.15.2002.1.16.
  17. D.J. Patel and V.P. Patel, Int. J. ChemTech Res., 2, 1930 (2010).
  18. V. Dighe, R. Sane, S. Menon, H. Tambe, S. Pillai and V. Gokarn, J. Planar Chromatogr.-Modern TLC, 19, 448 (2006); https://doi.org/10.1556/JPC.19.2006.6.7.
  19. R.N. Goyal, V.K. Gupta and S. Chatterjee, Sens. Actuators B Chem., 149, 252 (2010); https://doi.org/10.1016/j.snb.2010.05.019.
  20. R.T. Kachoosangi, G.G. Wildgoose and R.G. Compton, Anal. Chim. Acta, 618, 54 (2008); https://doi.org/10.1016/j.aca.2008.04.053.
  21. M.R. Khoshayand, H. Abdollahi, M. Shariatpanahi, A. Saadatfard and A. Mohammadi, Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 70, 494 (2008); https://doi.org/10.1016/j.saa.2007.07.033.
  22. E. Dinç, C. Yücesoy and F. Onur, J. Pharm. Biomed. Anal., 28, 1091 (2002); https://doi.org/10.1016/S0731-7085(02)00031-6.
  23. S.A. Shama, J. Pharm. Biomed. Anal., 30, 1385 (2002); https://doi.org/10.1016/S0731-7085(02)00437-5.
  24. I. Savic, G. Nikolic and V. Bankovic, Maced. J. Chem. Chem. Eng., 27, 149 (2008); https://doi.org/10.20450/mjcce.2008.235.
  25. M.A. Elsayed, A.C. Obiakara and S.U. Uzodinma, J. AOAC, 64, 861 (1981).
  26. K.T. Koshy and H. Mitchner, J. Pharm. Sci., 52, 802 (1963); https://doi.org/10.1002/jps.2600520821.
  27. C.A. Kelly and M.E. Auerbach, J. Pharm. Sci., 50, 490 (1961); https://doi.org/10.1002/jps.2600500610.
  28. Y.H. Zhu, Z.L. Zhang, W. Zhao and D.W. Pang, Sens. Actuators B Chem., 119, 308 (2006); https://doi.org/10.1016/j.snb.2005.12.026.
  29. M.B. Gholivand, G. Malekzadeh and M. Torkashvand, J. Elec. Chem., 704, 50 (2013).https://doi.org/10.1016/j.jelechem.2013.06.013.
  30. A.P. Dewani, B.B. Barik, V.D. Chipade, R.L. Bakal, A.V. Chandewar and S.K. Kanungo, Arab. J. Chem., 7, 811 (2014); https://doi.org/10.1016/j.arabjc.2012.07.010.
  31. F.T. Noggle, J. DeRuiter and C.R. Clark, Anal. Chem., 58, 1643 (1986); https://doi.org/10.1021/ac00121a011.
  32. S. Barkan, J.D. Weber and E. Smith, J. Chromatogr. A, 219, 81 (1981); https://doi.org/10.1016/S0021-9673(00)80576-2.
  33. H.X. Li, M.Y. Ding, K. Lv and J.Y. Yu, J. Chromatogr. Sci., 39, 370 (2001); https://doi.org/10.1093/chromsci/39.9.370.
  34. H.M. Elfatatry, M.M. Mabrouk, S.F. Hammad, F.R. Mansour, A.H. Kamal and S. Alahmad, J. AOAC, 99, 1247 (2016); https://doi.org/10.5740/jaoacint.16-0106.
  35. N.H. Al-Shaalan, J. Saudi Chem. Soc., 14, 15 (2010); https://doi.org/10.1016/j.jscs.2009.12.004
  36. O.A. Donmez, A. Bozdogan and G. Kunt, Chemia Analit, 52, 135 (2007).
  37. T. Aman, A. Ahmad, M. Aslam and M.A. Kashmiri, Anal. Lett., 35, 733 (2002); https://doi.org/10.1081/AL-120003173.
  38. S.I. Zayed and I.H. Habib, Farmaco, 60, 621 (2005); https://doi.org/10.1016/j.farmac.2005.05.003.
  39. M.S. Bhatia, S.G. Kaskhedikar and S.C. Chaturvedi, Indian J. Pharm. Sci., 62, 61 (2000).
  40. A. Manassra, M. Khamis, M. Dakiky, Z.A. Qader and F.A. Rimawi, J. Pharm. Biomed. Anal., 51, 991 (2010); https://doi.org/10.1016/j.jpba.2009.10.024.
  41. A.H. Beckett and J.B. Stenlake, Ultraviolet-Visible Spectroscopy: Difference Spectroscopy, Practical Pharmaceutical Chemistry, CBS Publishers Ltd., p. 275 (1998).
  42. S.L. Upstone, Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation, Wiley & Sons, p. 548 (2013).
  43. V.K. Redasani, P.R. Patel, D.Y. Marathe, S.R. Chaudhari, A.A. Shirkhedkar and S.J. Surana, J. Chil. Chem. Soc., 63, 4126 (2018); https://doi.org/10.4067/s0717-97072018000304126.
  44. M.C. Gutierrez, J. Inst. Brew., 98, 277 (1992); https://doi.org/10.1002/j.2050-0416.1992.tb01108.x.
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 1 Download : 0