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Vol. 31 No. 12 (2019): Vol 31 Issue 12

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High Yielding, Base Catalyzed C6 Regioselective Amination and N9 Alkylation in Purine Nucleotide

https://doi.org/10.14233/ajchem.2019.22235
Gautamkumar Dhuda
Department of Chemistry, Maharshi Dayanand Science College (Affilated to Bhakta Kavi Narsinh Mehta University), Porbandar-360575, India
Khushal Kapadiya
Department of Chemistry, B.R.C.C. Laboratory, School of Science, R K University, Rajkot-360020, India
https://orcid.org/0000-0001-9025-1177
Paresh Ladwa
Department of Chemistry, Maharshi Dayanand Science College (Affilated to Bhakta Kavi Narsinh Mehta University), Porbandar-360575, India
Bhavna Godhaniya
Department of Chemistry, Maharshi Dayanand Science College (Affilated to Bhakta Kavi Narsinh Mehta University), Porbandar-360575, India
Jayesh Modha
Department of Chemistry, Maharshi Dayanand Science College (Affilated to Bhakta Kavi Narsinh Mehta University), Porbandar-360575, India

Corresponding Author(s) : Khushal Kapadiya

khushal_kapadiya06@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

2,6-Dichloropurine is an interesting new nucleoside which gave regioselectively various 2-derivatized or 6-derivatized purines by using a secondary amines. An efficient, simple and regioselective synthesis of C6 morpholine, N9 alkylated purine nucleoside derivatives were attained via chloro-amine coupling reaction between 2,6-dichloropurine with morpholine followed by commercial alkylation method using DMF and K2CO3. Over the traditionally used protocols and procedure, it have been exhibited advance benefits such as admirable yield, simple reaction conditions and modest influence.

Keywords

2,6-Dichloropurine Regioselective Alkylation Amination
Dhuda, G., Kapadiya, K., Ladwa, P., Godhaniya, B., & Modha, J. (2019). High Yielding, Base Catalyzed C6 Regioselective Amination and N9 Alkylation in Purine Nucleotide. Asian Journal of Chemistry, 31(12), 2871–2874. https://doi.org/10.14233/ajchem.2019.22235
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