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Vol. 31 No. 12 (2019): Vol 31 Issue 12

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Role of Enzymes in Synthesis of Biologically Important Organic Scaffolds: A Review

https://doi.org/10.14233/ajchem.2019.22205
Khushbu Gupta
Department of Applied Sciences, The NorthCap University, Sector 23-A, Gurugram-122017, India
https://orcid.org/0000-0002-7316-4650
Tejpal Singh Chundawat
Department of Applied Sciences, The NorthCap University, Sector 23-A, Gurugram-122017, India
https://orcid.org/0000-0001-8666-4403

Corresponding Author(s) : Tejpal Singh Chundawat

chundawatchem@yahoo.co.in

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

Green route of biogenic synthesis of heterocyclic compounds via microbes (bacteria, fungi, virus, yeast, algae, etc.) has the potential to deliver clean manufacturing technology. The application of biocatalysts for the synthesis of novel compounds has attracted increasing attention over the past few years and consequently, high demands have been placed on the identification of new biocatalysts for organic synthesis. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies. The characteristics of biocatalyst can be tailored with protein engineering and metabolic engineering methods to meet the desired process conditions. This review discusses the synthetic application of all the six classes of enzymes which are oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase. Enzymes are highly selective catalysts and their contribution to regio-, chemo- and stereoselectivity of compounds were also discussed.

Keywords

Biogenic synthesis Biocatalyst Microorganisms Epoxidation
Gupta, K., & Chundawat, T. S. (2019). Role of Enzymes in Synthesis of Biologically Important Organic Scaffolds: A Review. Asian Journal of Chemistry, 31(12), 2698–2706. https://doi.org/10.14233/ajchem.2019.22205
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