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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Design, Synthesis and in vitro Anticancer Evaluation of New 2H-benzo[b][1,4]thiazin-3(4H)-one Based 1,2,3-Triazoles

https://doi.org/10.14233/ajchem.2019.22223
O. Rajender
Department of Chemistry, Kakatiya University, Warangal-506009, India
S. Narsimha
Department of Chemistry, Kakatiya University, Warangal-506009, India
https://orcid.org/0000-0002-1844-2937
N. Vasudeva Reddy
Department of Chemistry, Kakatiya University, Warangal-506009, India
https://orcid.org/0000-0002-8776-6986

Corresponding Author(s) : N. Vasudeva Reddy

vasujac3@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

A series of novel 2H-benzo[b][1,4]thiazin-3(4H)-one derived from 1,4-disubstituted 1,2,3-triazole derivatives (4a-j and 5a-j) were synthesized using Cu(I) catalyzed azide alkyne cyclization (CuAAC) reaction of the compounds 2 and 3 with various aromatic azides. The examination of in vitro anticancer activity revealed that the compounds 4d and 5d were found to possess a broad spectrum of anticancer activity against three cell lines MCF-7, HeLa and IMR-32 with IC50 values ranging from 26.28 ± 1.5 to 32.06 ± 0.3 M mL-1, respectively. The remaining compounds have shown good to moderate activity against the tested cell lines.

Keywords

2H-benzo[b][1,4]thiazin-3(4H)-one 1,2,3-triazole Anticancer activity
Rajender, O., Narsimha, S., & Reddy, N. V. (2019). Design, Synthesis and in vitro Anticancer Evaluation of New 2H-benzo[b][1,4]thiazin-3(4H)-one Based 1,2,3-Triazoles. Asian Journal of Chemistry, 31(11), 2647–2652. https://doi.org/10.14233/ajchem.2019.22223
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