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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Synthesis and Anticancer Activity of Novel Hetero Ring Fused Pyridine Amide Derivatives

https://doi.org/10.14233/ajchem.2019.22150
Hanumandlu Racha
Department of Chemistry, Telangana University, Dichpally, Nizamabad-503322, India
Balakishan Vadla
Department of Chemistry, Telangana University, Dichpally, Nizamabad-503322, India
Kavitha Peddolla
Department of Chemistry, Telangana University, Dichpally, Nizamabad-503322, India
Sailu Betala
Department of Chemistry, Telangana University, Dichpally, Nizamabad-503322, India

Corresponding Author(s) : Sailu Betala

bethalasailu@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

A series of novel hetero ring fused pyridine amide derivatives were prepared starting from ethyl furo[2,3-b]pyridine-2-carboxylate (3) on reaction with ammonia to afford furo[2,3-b]pyridine-2-carboxamide (4), compound 4 on reaction with trifluoroacetic acid to give compound 5, which on reaction with bromoethyl acetate followed by hydrazine hydrate to give compound 7. Compound 7 when reacted with different substituted aromatic aldehydes to give Schiff base compounds (8a-l). Similarly, compound 6a when reacted with diverse substituted aliphatic amines to give amide derivatives (9a-h). All the synthesized compounds 8a-l and 9a-h were screened for anticancer activity against four cancer cell lines such as A549-lung cancer (CCL-185); DU145-prostate cancer (HTB-81); SiHa-squamous cell carcinoma (HTB-35); MCF-7-breast cancer (HTB-22); HEK-29-human embryonic kidney cells (CRL-1573). Compounds 9e and 9f are found to have promising anticancer activity at micro molar concentration and found to be non-toxic on normal cell line.

Keywords

Schiff base Amide derivatives Trifluoromethyl group Anticancer activity
Racha, H., Vadla, B., Peddolla, K., & Betala, S. (2019). Synthesis and Anticancer Activity of Novel Hetero Ring Fused Pyridine Amide Derivatives. Asian Journal of Chemistry, 31(11), 2485–2491. https://doi.org/10.14233/ajchem.2019.22150
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