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Vol. 31 No. 10 (2019): Vol 31 Issue 10

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K2CO3/Al2O3: An Efficient and Recyclable Catalyst for One-Pot, Three Components Synthesis of α-Aminophosphonates and Bioactivity Evaluation

https://doi.org/10.14233/ajchem.2019.22194
G. Sravya
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia
https://orcid.org/0000-0002-6249-3870
G. Suresh
Anhui Provincial Engineering Technology Research Centre of New Silicon-Based Materials, Bengbu University, Caoshan Road 1866, Bengbu 233030, Anhui
Grigory V. Zyryanov
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia; I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of Russian Academy of Sciences, 22 S. Kovalevskoy Street, 620219, Yekaterinburg, Russia
A. Balakrishna
Rajeev Gandhi Memorial College of Engineering and Technology (Autonomous), Nandyal-518501, India
https://orcid.org/0000-0003-2866-4995
N. Bakthavatchala Reddy
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia
https://orcid.org/0000-0003-2039-9277

Corresponding Author(s) : N. Bakthavatchala Reddy

drbvreddyn@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 10 (2019): Vol 31 Issue 10

Abstract

A simple and efficient method has been employed for synthesis of a novel series of biologically active α-aminophosphonates (4a-j) by reacting 1H-benzo[d]imidazole-2-carbaldehyde (1) and various aromatic amines (2a-j) and diethyl/dimethyl phosphite (3) by Kabachnik-Field's reaction in the presence of efficient heterogeneous K2CO3/Al2O3 catalyst under solvent-free conditions at 140 ºC. Structures of all the compounds were confirmed by 1H, 13C and 31P NMR and LC-MS. In addition to this antioxidant activity were also evaluated.

Keywords

K2CO3/Al2O3 catalyst α-Aminophosphonates Antioxidant activity Kabachnik-Field′s reaction
Sravya, G., Suresh, G., Zyryanov, G. V., Balakrishna, A., & Reddy, N. B. (2019). K2CO3/Al2O3: An Efficient and Recyclable Catalyst for One-Pot, Three Components Synthesis of α-Aminophosphonates and Bioactivity Evaluation. Asian Journal of Chemistry, 31(10), 2383–2388. https://doi.org/10.14233/ajchem.2019.22194
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