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Vol. 27 No. 11 (2015): Vol 27 Issue 11

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Synthesis and Evaluation of Imidazo[2,1-d][1,2,3,5]tetrazine-4(3H)-one Derivatives as Anticancer and Antimicrobial Agents

https://doi.org/10.14233/ajchem.2015.19048
Saravanan Raji
Department of Chemistry, Islamiah College, Vaniyambadi-632 752, India
S. Raja Mohamed Kamil
Department of Chemistry, Islamiah College, Vaniyambadi-632 752, India
Paramasivam Subbaraj
Department of Chemistry, Devanga Arts College (Autonomous), Aruppukottai-626 101, India
Jeyaprakash Dharmaraja
Division of Chemistry, Faculty of Science and Humanities, Sree Sowdambika College of Engineering, Chettikurichi, Aruppukottai-626 134, India

Corresponding Author(s) : S. Raja Mohamed Kamil

rajamohamedkamil2014@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 11 (2015): Vol 27 Issue 11

Abstract

A series of novel potent hetero aromatic nitrogen ring of imidazo[2,1-d][1,2,3,5]tetrazine-4(3H)-one derivatives (1a-1i) have been synthesized from 5-propylthio-2-diazo-2H-benzimidazole with substituted isocyanates. The synthesized compounds were structurally characterized by using various analytical and spectral techniques. In vitro microbial activities of the ligands were screened against some pathogenic bacterial and fungal species by modified well diffusion method using agar medium. All the synthesized compounds show significant biological activity as compared to the standard control drugs. Furthermore, antiproliferative activities of these compounds have been investigated against some breast (MCF-7), prostate (PC-3), lung (H1975) and colon (HCT-116) cancer cell lines. The compound (1b) showed a noticeable antiproliferative activity against the entire cell lines than the others.

Keywords

Imidazotetrazinones Spectral studies Microbial activity Anticancer activity Cytotoxicities
Raji, S., Raja Mohamed Kamil, S., Subbaraj, P., & Dharmaraja, J. (2015). Synthesis and Evaluation of Imidazo[2,1-d][1,2,3,5]tetrazine-4(3H)-one Derivatives as Anticancer and Antimicrobial Agents. Asian Journal of Chemistry, 27(11), 4007–4012. https://doi.org/10.14233/ajchem.2015.19048
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