Copyright (c) 2009 T. Shivaraj Gouda, Jagadish, Md. Salahuddin, S.M. Shantakumar
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Antiinflammatory Activity of Some Novel Benzo(b)thiophene Substituted Thiazolidinones
Corresponding Author(s) : T. Shivaraj Gouda
Asian Journal of Chemistry,
Vol. 21 No. 7 (2009): Vol 21 Issue 7
Abstract
The 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylate (I) was prepared by treating an equimolar concentration of cyclohexanone, ethylcyanoacetate, sulphur and diethylamine in dry alcohal. The compound (II) was refluxed for about 18-20 h with different aromatic aldehydes in absolute alcohol to obtain III(a-f). The obtained intermediates are treated with mercapto acetic acid to get IV(a-f). The synthesized compounds were evaluated for antiinflammatory activity. The compound IVd and IVe showed significant activity when compared to standard diclofenac sodium.
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