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Vol. 27 No. 11 (2015): Vol 27 Issue 11

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Metal Complexes of Ceftriaxone as Potent Medication Against Ailment

https://doi.org/10.14233/ajchem.2015.18871
Muhammad Danish
Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan
Muhammad Asam Raza
Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan
Sehrish
Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan
Nargis Anjum
Department of Chemistry, University of Sargodha, Sargodha, Pakistan

Corresponding Author(s) : Muhammad Danish

drdanish62@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 11 (2015): Vol 27 Issue 11

Abstract

Metal-ceftriaxone complexes were synthesized by reacting sodium salt of ceftriaxone with metallic salts or organometallic halides in a common organic solvent that requires a few hours of stirring at certain temperature. These were then purified from an appropriate solvent/mixture of solvents using thin layer chromatography technique. Melting point and FTIR studies indicated the synthesis of the complexes. Infrared studies of the complexes confirmed that ligand bonded to metal ion through the carboxylate ion and the oxygen of the b-lactam thiozolidine ring. These studies have shown that complexes of Co, Ni, Fe, Cu and Sn possess octahedral geometry having d2sp3 hybridization. In the spectrum mode of UV/visible spectrophotometer, lmax was determined, close resemblance in the lmax values of ligand and complexes showed that chromophoric groups (C=O, C=C, C=N) were similar in both cases. Antibacterial studies have been carried out against Escherichia coli and Bacillus subtilis. SH-2 exhibited maximum antimicrobial activity against E. coli (7-29 mm). Antioxidant activity was carried out using diphenyl picryl hydrazyl (DPPH) as free radical, SH-5 and SH-7 showed excellent activity (96.03 ± 1.1 % and 87.00 ± 0.9 % respectively). Enzyme inhibition potential activity was checked against three available enzymes and it was concluded from results that SH-5 metal complex of Cu is more potent inhibitor than others (67.92 ± 1.5 %, 84.16 ± 1.7 % and 69.77 ± 1.3 % against protease, AChE and BChE respectively).

Keywords

Metal complexes Ceftriaxone DPPH Proteases AChE BChE
Danish, M., Asam Raza, M., Sehrish, ., & Anjum, N. (2015). Metal Complexes of Ceftriaxone as Potent Medication Against Ailment. Asian Journal of Chemistry, 27(11), 3925–3929. https://doi.org/10.14233/ajchem.2015.18871
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