Synthesis and Antimicrobial Activity of New Imidazole-Hydrazone Derivatives

V. Laxmi Prasanna; R. Narender

doi:10.14233/ajchem.2015.18886

Issue

Vol. 27 No. 10 (2015): Vol 27 Issue 10

Issue Published : June 22, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antimicrobial Activity of New Imidazole-Hydrazone Derivatives

https://doi.org/10.14233/ajchem.2015.18886

V. Laxmi Prasanna

Vignan Institute of Technology & Science, Vignan Hills, Deshmukhi (Village), Nalgonda (District), Hyderabad-508 284, India; Department of Humanities & Science, Jawaharlal Nehru Institute of Technology, Ibrahimpatnam, Hyderabad-501 510, India

R. Narender

Department of Humanities & Science, Jawaharlal Nehru Institute of Technology, Ibrahimpatnam, Hyderabad-501 510, India

Corresponding Author(s) : V. Laxmi Prasanna

v.laxmi.prasanna.2014@gmail.com

Asian Journal of Chemistry, Vol. 27 No. 10 (2015): Vol 27 Issue 10
Article Published : June 22, 2015

Abstract

Hydrazones demonstrated significant antimicrobial activity, antitubercular activity and antitumoral activity in medicinal areas. The imidazole nucleus is well known to play an important role in living organisms since it is incorporated into the histidine molecule and many other important biological, pharmacological and therapeutic activities. Condensation of 4-phenyl-1H-imidazole-2-carbaldehyde (3) with various selected benzohydrazides (4a-m) resulted in imidazole-hydrazone derivatives (5a-m). They were evaluated for antibacterial and antifungal activity against A. niger, C. albicans (fungal strains), E. coli and P. aeruginosa (Gram-negative bacteria), S. aureus and S. pyogenes (Gram-positive bacteria) using griseofluvin (for fungi) and ciprofloxacin (for bacteria) as the standard drugs. In general, it is observed that most of the compounds were found to be potent against both the bacterial and fungal strains.

Keywords

Antibacterial activity Antifungal activity Imidazoles Hydrazones Synthesis

Laxmi Prasanna, V., & Narender, R. (2015). Synthesis and Antimicrobial Activity of New Imidazole-Hydrazone Derivatives. Asian Journal of Chemistry, 27(10), 3605–3608. https://doi.org/10.14233/ajchem.2015.18886

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References

J.G. Lombardino and E.H. Wiseman, J. Med. Chem., 17, 1182 (1974); doi:10.1021/jm00257a011.

J.G. Lombardino, Ger. Offen. 2,155,558 (1972); Chem. Abstr., 77, 101607y (1972).

A.P. Phillips, H.L. White and S. Rosen, Eur. Pat. Appl. EP, 58,890 (1982); Chem. Abstr., 98, 53894z (1983).

J.C. Lee, J.T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Keys, S.W. Land vatter, J.E. Strickler, M.M. McLaughlin, I.R. Siemens, S.M. Fisher, G.P. Livi, J.R. White, J.L. Adams and P.R. Young, Nature, 372, 739 (1994); doi:10.1038/372739a0.

A.S. Bell, in eds.: D.S. Jonhson and J.J. Li, The Art of Drug Synthesis; John Wiley & Sons, Inc.: Hoboken, NJ, USA, pp. 72–73 (2007).

B. Narasimhan, D. Sharma and P. Kumar, Med. Chem. Res., 20, 1119 (2011); doi:10.1007/s00044-010-9472-5.

S.G. Kucukguzel, E.E. Oruç, S. Rollas, F. Şahin and A. Özbek, Eur. J. Med. Chem., 37, 197 (2002); doi:10.1016/S0223-5234(01)01326-5.

S. Rollas, N. Gülerman and H. Erdeniz, Farmaco, 57, 171 (2002); doi:10.1016/S0014-827X(01)01192-2.

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X.D. Yang, J. Chem. Res., 489 (2008); doi:10.3184/030823408X340799.

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A.B. Samel and N.R. Pai, J. Chem. Pharm. Res, 2, 60 (2010).

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P. Vicini, M. Incerti, I.A. Doytchinova, P. La Colla, B. Busonera and R. Loddo, Eur. J. Med. Chem., 41, 624 (2006); doi:10.1016/j.ejmech.2006.01.010.

Issue

Vol. 27 No. 10 (2015): Vol 27 Issue 10

Synthesis and Antimicrobial Activity of New Imidazole-Hydrazone Derivatives

Corresponding Author(s) : V. Laxmi Prasanna

Abstract

Keywords

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