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Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Copyright (c) 2024 SANDIP SEN SANDIP

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Multi Receptor Targeting of Potential Bioactive Compound Obtained from Chloroform Extract of Asparagus racemosus by GC-MS Analysis: A in silico Based Approach

https://doi.org/10.14233/ajchem.2024.31671
Shaik Harun Rasheed
Department of Pharmaceutical Chemistry, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam-501506, India
https://orcid.org/0000-0002-3698-3331
Sayyad Mustak
Department of Pharmaceutical Chemistry, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam-501506, India
https://orcid.org/0000-0002-5333-9783
Chandan Mohanty
Department of Pharmaceutical Chemistry, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam-501506, India
https://orcid.org/0000-0002-5776-2802
Ravi Kumar Vakkalagadda
Department of Pharmaceutical Chemistry, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam-501506, India
https://orcid.org/0000-0003-0643-1103
Sandip Sen
Department of Pharmaceutical Chemistry, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam-501506, India
https://orcid.org/0000-0002-6118-8567

Corresponding Author(s) : Sandip Sen

sandipsen2010@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Abstract

Previous reports indicate that the medicinal plants and their components have been utilized for treating diverse conditions since antiquity. Asparagus racemosus, in particular, demonstrates a broad spectrum of therapeutic possibilities. This study aimed to underscores the potential bioactive compounds found within the chloroform extract of Asparagus racemosus. Gas-chromatography employed to identify the presence of various molecules, while mass spectrometry and FTIR analysis validated their molecular structures. The molecules were analyzed to assess its suitability as a therapeutic candidate, their biological activity and predicted targets using in silico techniques. The chloroform extract stands out as the richest reservoir of carbohydrates and steroidal alkaloids. Molecule (5β)-pregnane-3,20β-diol, 14α,18α-[4-methyl-3-oxo-(1-oxa-4-azabutane-1,4-diyl)]diacetate was found in the highest concentration (42.28 %). The identified molecule is a steroidal alkaloid in nature and the computational analysis revealed promising drug-like properties and therapeutic potential for the investigated molecule.

Keywords

Asparagus racemosus Chloroform Gas chromatography Mass spectroscopy Drug likeliness Target prediction
Rasheed, S. H., Mustak, S., Mohanty, C., Vakkalagadda, R. K., & Sen, S. (2024). Multi Receptor Targeting of Potential Bioactive Compound Obtained from Chloroform Extract of Asparagus racemosus by GC-MS Analysis: A in silico Based Approach. Asian Journal of Chemistry, 36(8), 1903–1911. https://doi.org/10.14233/ajchem.2024.31671
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