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Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

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CuI Promoted Efficient Synthesis and Antimicrobial Activity of Substituted 8,8-Dimethyl-5-phenyl-2-(pyrazin-2-yl)-5,7,8,9-tetrahydro-6H-[1,3,4]thiadiazolo[2,3-b]quinazolin-6-one

https://doi.org/10.14233/ajchem.2024.30890
N. Sridevi Khadgamala
Trans-Disciplinary Research Hub-Andhra University, Visakhapatnam-530003, India
V. Narasinga Rao
Department of Organic Chemistry & Biochemistry, PRISM PG & DG College, Visakhapatnam-530016, India
K. Apparao
Department of Chemistry, Dr. B.R. Ambedkar University, Srikakulam-532410, India
B.V Durgarao
Department of DFS (Chemistry), Oil & Natural Gas Corporation (ONGC), Rajamahendravaram-533106, India
B.S. Diwakar
Department of Engineering Chemistry, Sagi Rama Krishnam Raju Engineering College, Bhimavaram-534204, India
N. Krishna Rao
Department of Organic Chemistry & Biochemistry, PRISM PG & DG College, Visakhapatnam-530016, India

Corresponding Author(s) : N. Krishna Rao

naallakrishnarao@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Abstract

In present study, an efficient synthesis of substituted 5,7,8,9-tetrahydro-6H-[1,3,4]thiadiazolo[2,3-b]quinazolin-6-one compounds promoted by CuI as catalyst was carried out. These derivatives were obtained from 1,3,4-thiadiazol-2-amine, dimedone and substituted aromatic aldehyde in presence of CuI in ethanol as solvent at 70 ºC. Initially, 1,3,4-thiadiazol-2-amine was synthesized from pyrazine-3- carboxylic acid reacted with thiosemicarbazide in the presence of 50% H2SO4 in acetonitrile at 70 ºC. All the newly obtained derivatives  were evaluated by the spectroscopic techniques such as 1H NMR, 13C NMR and LCMS and structural determination of titled analogous  were analyzed by elemental analysis. The antibacterial activities of the newly synthesized compounds were also screened. 

Keywords

Pyrazine-3-carboxylic acid 1,3,4-Thiadiazol-2-amine Dimedone Substituted aromatic aldehyde Antimicrobial activity
Khadgamala, N. S., Rao, V. N., Apparao, K., Durgarao, B., Diwakar, B., & Rao, N. K. (2024). CuI Promoted Efficient Synthesis and Antimicrobial Activity of Substituted 8,8-Dimethyl-5-phenyl-2-(pyrazin-2-yl)-5,7,8,9-tetrahydro-6H-[1,3,4]thiadiazolo[2,3-b]quinazolin-6-one. Asian Journal of Chemistry, 36(4), 895–900. https://doi.org/10.14233/ajchem.2024.30890
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