Copyright (c) 2015 Q.K. Wang, S.P. Pu
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and in vitro Cytotoxicity of Novel Platinum(II) Complexes
Corresponding Author(s) : Q.K. Wang
Asian Journal of Chemistry,
Vol. 27 No. 5 (2015): Vol 27 Issue 5
Abstract
Four novel multinuclear platinum(II) complexes with 1R,2R-diaminocyclohexane, Pt-S coordination bond and dicarboxylic acid ion chains as bridges, were designed, prepared and spectrally characterized. The in vitro cytotoxicities of the new compounds were evaluated against HL-60, SMMC-7721, A-549, MCF-7 and SW480 human tumor cell lines by MTT assay. The results indicated that all compounds showed cytotoxicity, particularly, complex 1a, which has oxalic acid ion as a bridge, showed comparable anticancer activity to oxaliplatin against HL-60 and SMMC-7721.
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References
M.S. Davies, D.S. Thomas, A. Hegmans, S. Berners-Price and N. Farrell, Inorg. Chem., 41, 1101 (2002).
N. Margiotta, R. Ostuni, V. Gandin, C. Marzano, S. Piccinonna and G. Natile, Dalton Trans., 48, 10904 (2009).
S. Piccinonna, N. Margiotta, C. Pacifico, A. Lopalco, N. Denora, S. Fedi, M. Corsini and G. Natile, Dalton Trans., 41, 9689 (2012).
S. Komeda, H. Takayama, T. Suzuki, A. Odani, T. Yamori and M. Chikuma, Metallomics, 5, 461 (2013).
B.A.J. Jansen, J. van der Zwan, H. den Dulk, J. Brouwer and J. Reedijk, J. Med. Chem., 44, 245 (2001).
E.T. Martins, H. Baruah, J. Kramarczyk, G. Saluta, C.S. Day, G.L. Kucera and U. Bierbach, J. Med. Chem., 44, 4492 (2001).
Y. Wang, N. Farrell and J.D. Burgess, J. Am. Chem. Soc., 123, 5576 (2001).
E. Kodama, S. Shigeta, T. Suzuki and E.D. Clercq, Antiviral Res., 31, 159 (1996).